Sex‐specific effects of high‐fat diet on cognitive impairment in a mouse model of VCID
| Autor: | Abigail E. Salinero, Lisa S. Robison, David Riccio, Olivia J. Gannon, Kristen L. Zuloaga, Charly Abi-Ghanem, Febronia Mansour |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Physiology Diet High-Fat Biochemistry Article Mice 03 medical and health sciences Sex Factors 0302 clinical medicine Diabetes mellitus Genetics Animals Medicine Dementia Cognitive Dysfunction Prediabetes Risk factor Maze Learning Molecular Biology Spatial Memory business.industry Dementia Vascular Cognition medicine.disease Obesity Mice Inbred C57BL Disease Models Animal 030104 developmental biology Cerebral blood flow Female medicine.symptom business Weight gain 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | FASEB J |
| ISSN: | 1530-6860 0892-6638 |
| Popis: | Mid-life metabolic disease (ie, obesity, diabetes, and prediabetes) causes vascular dysfunction and is a risk factor for vascular contributions to cognitive impairment and dementia (VCID), particularly in women. Using middle-aged mice, we modeled metabolic disease (obesity/prediabetes) via chronic high-fat (HF) diet and modeled VCID via unilateral common carotid artery occlusion. VCID impaired spatial memory in both sexes, but episodic-like memory in females only. HF diet caused greater weight gain and glucose intolerance in middle-aged females than males. HF diet alone impaired episodic-like memory in both sexes, but spatial memory in females only. Finally, the combination of HF diet and VCID elicited cognitive impairments in all tests, in both sexes. Sex-specific correlations were found between metabolic outcomes and memory. Notably, both visceral fat and the pro-inflammatory cytokine tumor necrosis factor alpha correlated with spatial memory deficits in middle-aged females, but not males. Overall, our data show that HF diet causes greater metabolic impairment and a wider array of cognitive deficits in middle-aged females than males. The combination of HF diet with VCID elicits deficits across multiple cognitive domains in both sexes. Our data are in line with clinical data, which shows that mid-life metabolic disease increases VCID risk, particularly in females. |
| Databáze: | OpenAIRE |
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