Differential Localization of Acid-Sensing Ion Channels 1 and 2 in Human Cutaneus Pacinian Corpuscles
| Autor: | Juan Cobo, M.G. Calavia, O. García-Suarez, J. A. Montaño, Jorge Feito, M. E. Del Valle, José A. Vega, Pablo Perez-Pinera, M. A. Guervós, Antonino Germanà |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Epithelial sodium channel Pathology medicine.medical_specialty Adolescent Nerve Tissue Proteins Biology S100 protein Sodium Channels Young Adult Cellular and Molecular Neuroscience medicine Humans Mechanotransduction Axon Child Ion channel Acid-sensing ion channel Skin Mechanosensation ASIC proteins Cell Biology General Medicine Middle Aged Human Immunohistochemistry Mechanoreceptors Pacinian corpuscles Axons Cell biology Acid Sensing Ion Channels Protein Transport medicine.anatomical_structure Pacinian Corpuscles |
| Zdroj: | Cellular and Molecular Neurobiology. 30:841-848 |
| ISSN: | 1573-6830 0272-4340 |
| DOI: | 10.1007/s10571-010-9511-2 |
| Popis: | Acid-sensing ion channels (ASICs) are the members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily which mediate different sensory modalities including mechanosensation. ASICs have been detected in mechanosensory neurons as well as in peripheral mechanoreceptors. We now investigated the distribution of ASIC1, ASIC2, and ASIC3 proteins in human cutaneous Pacinian corpuscles using immunohistochemistry and laser confocal-scanner microscopy. We detected different patterns of expression of these proteins within Pacinian corpuscles. ASIC1 was detected in the central axon co-expressed with RT-97 protein, ASIC2 was expressed by the lamellar cells of the inner core co-localized with S100 protein, and ASIC3 was absent. These results demonstrate for the first time the differential distribution of ASIC1 and ASIC2 in human rapidly adapting low-threshold mechanoreceptors, and suggest specific roles of both proteins in mechanotransduction. |
| Databáze: | OpenAIRE |
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