Intracellular Pathogen Detection by RIG-I-Like Receptors
| Autor: | Jonathan C. Kagan, Evelyn Dixit |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Intracellular Fluid
Interferon-Induced Helicase IFIH1 viruses Nerve Tissue Proteins Receptors Cell Surface chemical and pharmacologic phenomena Biology Article Proinflammatory cytokine DEAD-box RNA Helicases RNA Virus Infections Interferon medicine Animals Humans Receptors Immunologic DEAD Box Protein 58 Innate immune system RIG-I LGP2 Membrane Proteins Bacterial Infections biochemical phenomena metabolism and nutrition Acquired immune system Virology Cell biology Receptors Pattern Recognition Host-Pathogen Interactions Signal transduction RNA Helicases Signal Transduction medicine.drug |
| Zdroj: | Advances in Immunology |
| Popis: | The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|