Activation of the signal transducer and activator of transcription-1 in diffuse proliferative lupus nephritis
| Autor: | J Majó-Masferrer, L Martinez-Lostao, Josep Ordi-Ros, Moises Labrador-Horrillo, Miquel Vilardell-Tarrés, A Segarra-Medrano, Eva Balada |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Biopsy Kidney Glomerulus Lupus nephritis 030204 cardiovascular system & hematology Severity of Illness Index Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology medicine Humans Cell Proliferation 030203 arthritis & rheumatology Creatinine medicine.diagnostic_test biology business.industry Middle Aged medicine.disease Immunohistochemistry Lupus Nephritis STAT1 Transcription Factor chemistry Disease Progression STAT protein biology.protein Female Renal biopsy Antibody business Biomarkers Follow-Up Studies |
| Zdroj: | Lupus. 16:483-488 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203307079618 |
| Popis: | Difuse proliferative lupus nephritis (DPLN) is the most common and severe form of lupus nephritis. A predominance of IFN-γ-producing T cells in both peripheral and renal tissues of patients with DPLN has been identified which suggests an important role for cell-mediated immunity in the pathogenesis of this complication in SLE. The biological effects of IFN-γ rely mainly on the activity of the transcription factor called signal transducer and activator of transcription (STAT)-1. To assess the IFN-γ/STAT-1 pathway in DPLN, we examined the expression of STAT-1 in renal biopsies from 15 DPLN patients by immunohistochemical staining with an anti-STAT-1 antibody. The expression of STAT-1 in renal tissues was correlated with several clinical and laboratory findings in these DNPN patients.STAT-1 was activated in the tubular cells in all DPLN patients. Seven of 15 DPLN biopsies (46.7%) showed positive cells in glomeruli. Five of these seven DPLN biopsies (71.4%) with positive glomerular cells showed a serum creatinine >1.5 mg/mL at the time the biopsy was carried out whereas only one of eight DPLN biopsy specimens (12.5%) without positive glomerular cells, showed a serum creatinine >1.5 mg/mL ( P = 0.041). Moreover, the percentage of DPLN patients with a worse renal outcome in those who showed expression of STAT-1 in glomerulari were higher in comparison to those without STAT-1 expression ( P = 0.041).Our results show that STAT-1 is activated in DPLN suggesting that biological effects of IFN-γ in renal tissues depend, at least in part, on the activation of STAT-1. Lupus (2007) 16, 483—488. |
| Databáze: | OpenAIRE |
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