Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/β-catenin signaling pathway
| Autor: | Ming Zhong, Min-Hao Yu, Jian-Jun Chen, Yi-Zhou Huang, Qiang Lv, Jun Qin, Yang Luo |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Cancer Research Colorectal cancer Mice Nude Biology Binding Competitive Metastasis 03 medical and health sciences 0302 clinical medicine Sirtuin 1 Cell Line Tumor medicine Animals Humans Wnt Signaling Pathway beta Catenin Aged Mice Inbred BALB C Oncogene Cell growth Competing endogenous RNA Wnt signaling pathway Middle Aged HCT116 Cells medicine.disease Long non-coding RNA Up-Regulation MicroRNAs 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Heterografts Female RNA Long Noncoding Caco-2 Cells Signal transduction Colorectal Neoplasms HT29 Cells |
| Zdroj: | Cancer Letters. :11-22 |
| ISSN: | 0304-3835 |
| Popis: | In recent years, accumulating evidence has indicated that long non-coding RNAs (lncRNAs) are powerful factors influencing the progression of multiple malignancies. Although a relationship between the lncRNA NEAT1 (nuclear enriched abundant transcript 1) and colorectal cancer has previously been reported, the functional mechanism underlying the involvement of NEAT1 in colorectal cancer remains unknown. In this study, we report that NEAT1 expression is up-regulated in colorectal cancer tissues, which correlates with advanced clinical features, poor overall survival and disease free survival. Up-regulated NEAT1 promotes cell proliferation and metastasis of colorectal cancer both in vitro and in vivo. Moreover, NEAT1 functions as an oncogene influencing cell viability and invasion in part by serving as a competing endogenous RNA (ceRNAs) modulating miRNA-34a expression, leading to subsequent repression of the miR-34a/SIRT1 axis and activation of the Wnt/β-catenin signaling pathway. Taken together, our study demonstrates that the lncRNA NEAT1 may serve as a prognostic biomarker and a potential therapeutic target in colorectal cancer. |
| Databáze: | OpenAIRE |
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