A population-based approach for the definition of chronic kidney disease: the CKD Prognosis Consortium
| Autor: | Cinzia Lombardi, Fabiana Marcarelli, Giancarlo Bilancio, Massimo Cirillo, Alessandra Antonia Mele |
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| Přispěvatelé: | Cirillo, M, Lombardi, C, Mele, Aa, Marcarelli, F, Bilancio, G. |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Population Renal function urologic and male genital diseases chemistry.chemical_compound Risk Factors Internal medicine Albuminuria Humans Medicine Renal Insufficiency Chronic education Intensive care medicine Aged education.field_of_study Creatinine Proteinuria business.industry Incidence (epidemiology) Age Factors Absolute risk reduction Middle Aged Prognosis medicine.disease female genital diseases and pregnancy complications chemistry Nephrology medicine.symptom business Glomerular Filtration Rate Kidney disease |
| Popis: | Introduction: The Kidney Disease: Improving Global Outcomes (KDIGO) foundation promoted the establishment of the Chronic Kidney Disease (CKD) Prognosis Consortium to meta-analyze the association of estimated glomerular filtration rate (eGFR) and albuminuria with incidence of various outcomes in samples of general populations from all over the world. Methods: Variables in meta-analysis included eGFR by the Modification of Diet in Renal Disease (MDRD) Study equation, the urinary albumin to creatinine ratio (uACR) as index of albuminuria, together with proteinuria at dipstick urinalysis and classical markers of cardiovascular risk. Overall, 105,872 participants had uACR measurements, and 1,128,310 participants had dipstick measurements. Results: The association with mortality was continuous over the whole range of uACR/proteinuria and Jshaped for eGFR which was associated with an excess risk for values |
| Databáze: | OpenAIRE |
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