Two cases of t(1;16)(p11;p11) in multiple myeloma: Confirmation by chromosome painting
| Autor: | Nathalie Trillot, M. Flactif, Thierry Facon, Francis Bauters, Marc Zandecki, Franck Bernardi, Jean Luc Laï |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Cancer Research Conventional cytogenetics Chromosomal translocation Biology Translocation Genetic Immunopathology Genetics medicine Humans Molecular Biology In Situ Hybridization Fluorescence Multiple myeloma Aged medicine.diagnostic_test Middle Aged medicine.disease Molecular biology Molecular hybridization Chromosomes Human Pair 1 Karyotyping Fish Female Chromosome painting Multiple Myeloma Chromosomes Human Pair 16 Fluorescence in situ hybridization |
| Zdroj: | Cancer Genetics and Cytogenetics. 76:10-14 |
| ISSN: | 0165-4608 |
| Popis: | Two patients with multiple myeloma and an unbalanced translocation, t(1;16)(p11;p11), are reported. The fluorescence in situ hybridization (FISH) technique was used in one patient to confirm the translocation. To our knowledge, t(1;16)(p36;q13) and t(1;16)(q21;p13), but not t(1;16)(p11;p11), had been reported previously in multiple myeloma. Our results suggest that FISH is useful to characterize structural abnormalities and identify marker chromosomes in multiple myeloma where analysis with conventional cytogenetics is often difficult. |
| Databáze: | OpenAIRE |
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