Upper Airway Findings and Markers of Lung Disease Progression in Patients with Cystic Fibrosis
| Autor: | Nédio Steffen, Luciane Mazzini Steffen, Luíse Sgarabotto Pezzin, Leonardo Araújo Pinto, Natassia Sulis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Nasal cavity
medicine.medical_specialty lcsh:Medicine respiratory tract infections Cystic fibrosis Gastroenterology cystic fibrosis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Nasal polyps Respiratory system Original Research 030304 developmental biology 0303 health sciences nasal polyps Respiratory tract infections business.industry lcsh:R respiratory system lcsh:Otorhinolaryngology medicine.disease lcsh:RF1-547 medicine.anatomical_structure 030228 respiratory system Otorhinolaryngology Nasal Swab Airway business bacteriology Respiratory tract |
| Zdroj: | International Archives of Otorhinolaryngology, Volume: 24, Issue: 4, Pages: 434-437, Published: 16 NOV 2020 International Archives of Otorhinolaryngology v.24 n.4 2020 International Archives of Otorhinolaryngology Fundação Otorrinolaringologia (FORL) instacron:FORL International Archives of Otorhinolaryngology, Vol 24, Iss 04, Pp e434-e437 (2020) |
| Popis: | Introduction Cystic fibrosis (CF) is a genetic disease that limits the quality of life mainly due to respiratory symptoms. The relationship between findings of the upper airways and CF lung disease is not yet completely understood. Objective The aim of the present study is to describe the most frequent nasal findings and pathogens in patients with CF and investigate the association between the findings of the upper respiratory tract and markers of lung disease progression. Methods Retrospective study in patients with CF from the Pediatric Pulmonology Department who underwent otorhinolaryngological evaluation between 2015 and 2017. Nasal endoscopy and nasal swab collection were part of the evaluation. The severity markers used were: percentage of predicted forced expiratory volume in the first second (FEV1%), body mass index (BMI) and the Shwachman-Kulczycki (SK) clinical score. Results A total of 48 patients with CF were included. The mean of the predicted percentage of FEV1% was 83.36 ± 30.04. The average 14 and SK score 89.11 ± 10.50. The bacteriology of the nasal swab was positive in 27 (54.1%) patients. Staphylococcus aureus was positive in 18 patients, Pseudomonas aeruginosa in 5, Pseudomonas cepacea in 3 and Stenotrophomonas maltophila in 1 patient. Nasal polyps were found in nine participants. Nasal polyps were found in nine participants and were associated with lower SK score. Conclusion The pathogens found in the upper airway were, in order: S. aureus, P. aeruginosa, P. cepacea e S. maltophila. The presence of polyps in the nasal cavity showed statistical significance and appears to have association with the prognostic factor measured by the SK score. |
| Databáze: | OpenAIRE |
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