Endotoxin induced production of interleukin-6 is enhanced by vitamin E deficiency and reduced by black tea extract
| Autor: | R. F. Grimble, P. S. Tappia, A.M.T. Amarakoon |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Antioxidant Lipopolysaccharide Polymers medicine.medical_treatment Immunology Enzyme-Linked Immunosorbent Assay Weight Gain Random Allocation chemistry.chemical_compound Phenols Internal medicine medicine Animals Vitamin E Vitamin E Deficiency Rats Wistar Interleukin 6 Flavonoids Pharmacology Analysis of Variance Tea biology Interleukin-6 Plant Extracts Acute-phase protein Ceruloplasmin Polyphenols Glutathione Rats Endocrinology Liver Biochemistry chemistry Polyphenol biology.protein Spectrophotometry Ultraviolet Vitamin E deficiency |
| Zdroj: | Inflammation Research. 44:301-305 |
| ISSN: | 1420-908X 1023-3830 |
| DOI: | 10.1007/bf02032573 |
| Popis: | Studies were performed to investigate the effect of a polyphenol rich extract from black tea and vitamin E on bacterial lipopolysaccharide (endotoxin) induced IL-6 production, alterations in liver glutathione and antioxidant acute phase protein (caeruloplasmin) concentration, in rats fed on a synthetic diet for 21 days. In the vitamin E sufficient group a significantly lower IL-6 concentration than in vitamin E deficient animals was observed. Addition of tea extract to the diet produced a similar reduction in IL-6, but no synergism occurred in the presence of both vitamin E and tea extract. However, a significantly lower caeruloplasmin and a significantly higher liver glutathione concentration was observed in rats fed both substances. It is suggested that consideration of dietary components which alter antioxidant/oxidant status may contribute towards treatment of inflammatory/autoimmune diseases. |
| Databáze: | OpenAIRE |
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