Titanium dioxide nanoparticles: some aspects of toxicity/focus on the development
| Autor: | Aurelia Liskova, Sona Scsukova, Jevgenij Kovriznych, Alzbeta Mlynarcikova, Alexander Kiss, Miroslava Kuricova, Jana Tulinska, Eva Rollerova |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Placenta Endocrinology Diabetes and Metabolism Developmental toxicity Metal Nanoparticles Nanotechnology Intestinal absorption Toxicology chemistry.chemical_compound Endocrinology Pregnancy Animals Humans Toxicokinetics Tissue Distribution Titanium Chemistry Environmental Exposure Food packaging Intestinal Absorption Blood-Brain Barrier Nanotoxicology Inactivation Metabolic Titanium dioxide Toxicity Female Growth and Development Reproductive toxicity |
| Zdroj: | Endocrine Regulations. 49:97-112 |
| ISSN: | 1336-0329 |
| DOI: | 10.4149/endo_2015_02_97 |
| Popis: | Nanosized titanium dioxide (TiO2) particles belong to the most widely manufactured nanoparticles (NPs) on a global scale because of their photocatalytic properties and the related surface effects. TiO2 NPs are in the top five NPs used in consumer products. Ultrafine TiO2 is widely used in the number of applications, including white pigment in paint, ceramics, food additive, food packaging material, sunscreens, cosmetic creams, and, component of surgical implants. Data evidencing rapid distribution, slow or ineffective elimination, and potential long-time tissue accumulation are especially important for the human risk assessment of ultrafine TiO2 and represent new challenges to more responsibly investigate potential adverse effects by the action of TiO2 NPs considering their ubiquitous exposure in various doses. Transport of ultrafine TiO2 particles in systemic circulation and further transition through barriers, especially the placental and blood-brain ones, are well documented. Therefore, from the developmental point of view, there is a raising concern in the exposure to TiO2 NPs during critical windows, in the pregnancy or the lactation period, and the fact that human mothers, women and men in fertile age and last but not least children may be exposed to high cumulative doses. In this review, toxicokinetics and particularly toxicity of TiO2 NPs in relation to the developing processes, oriented mainly on the development of the central nervous system, are discussed Keywords: nanoparticles, nanotoxicity, nanomaterials, titanium dioxide, reproductive toxicity, developmental toxicity, blood brain barrier, placental barrier. |
| Databáze: | OpenAIRE |
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