Three-phase 18F-fluorocholine PET/CT in the evaluation of prostate cancer recurrence

Autor: Raymond Miralbell, Haleem G. Khan, Michael Wissmeyer, Hansjoerg Vees, O. Berrebi, Ch Steiner, Osman Ratib, Michel P. Kossovsky, Franz Buchegger, Habib Zaidi
Rok vydání: 2009
Předmět:
Male
medicine.medical_specialty
Fluorine Radioisotopes
Fluorine Radioisotopes/*diagnostic use
Urinary system
medicine.medical_treatment
Prostate-Specific Antigen/blood
Choline/*analogs & derivatives/diagnostic use
Prostatic Neoplasms/pathology/radiography/*radionuclide imaging
ddc:616.0757
Choline
Prostate cancer
Text mining
Recurrence
Biopsy
medicine
Humans
Radiology
Nuclear Medicine and imaging
Aged
Neoplasm Staging
Retrospective Studies
Aged
80 and over
PET-CT
medicine.diagnostic_test
business.industry
Cancer
Prostatic Neoplasms
General Medicine
Middle Aged
Prostate-Specific Antigen
medicine.disease
Radiation therapy
Prostate Bed
Positron-Emission Tomography
Radiology
Neoplasm Recurrence
Local
Nuclear medicine
business
Tomography
X-Ray Computed
Neoplasm Recurrence
Local/pathology/radiography/radionuclide imaging
Zdroj: Nuklearmedizin, Vol. 48, No 1 (2009) pp. 1-9; quiz N2-3
ISSN: 0029-5566
Popis: Summary Aim: Contribution of 3-phase 18F-fluorocholine PET/CT in suspected prostate cancer recurrence at early rise of PSA. Patients, methods: Retrospective analysis was performed in 47 patients after initial treatment with radiotherapy (n = 30) or surgery (n = 17). Following CT, 10 minutes list-mode PET acquisition was done over the prostate bed after injection of 300 MBq of 18F-fluorocholine. Three timeframes of 3 minutes each were reconstructed for analysis. All patients underwent subsequent whole body PET/CT. Delayed pelvic PET/CT was obtained in 36 patients. PET/CT was interpreted visually by two observers and SUVmax determined for suspicious lesions. Biopsies were obtained from 13 patients. Results: Biopsies confirmed the presence of cancer in 11 of 13 patients with positive PET for a total of 15 local recurrences in which average SUVmax increased during 14 minutes post injection and marginally decreased in delayed scanning. Conversely inguinal lymph nodes with mild to moderate metabolic activity on PET showed a clearly different pattern with decreasing SUVmax on dynamic images. Three-phase PET/CT contributed to the diagnostic assessment of 10 of 47 patients with biological evidence of recurrence of cancer. It notably allowed the discrimination of confounding blood pool or urinary activity from suspicious hyperactivities. PET/CT was positive in all patients with PSA ≥ 2 ng/ml (n = 34) and in 4/13 patients presenting PSA values
Databáze: OpenAIRE
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