Carbon Coating of Stents Has No Effect on Inflammatory Response to Primary Stent Deployment
| Autor: | Mehmet Emin Korkmaz, Aylin Yildirir, Melek Uluçam, Haldun Muderrisoglu, Egemen Tayfun, Bülent Özin, Münire Turan |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_treatment 030204 cardiovascular system & hematology Coronary Angiography Fibrinogen Random Allocation 0302 clinical medicine Coated Materials Biocompatible Risk Factors Leukocytes 030212 general & internal medicine Angioplasty Balloon Coronary biology Interleukin Middle Aged C-Reactive Protein medicine.anatomical_structure Data Interpretation Statistical Cytokines Female Stents medicine.symptom Cardiology and Cardiovascular Medicine medicine.drug Adult medicine.medical_specialty Urology Inflammation Angina Pectoris 03 medical and health sciences medicine Humans Angina Unstable Interleukin 6 Aged Interleukin-6 business.industry C-reactive protein Coronary Stenosis Stent Stainless Steel medicine.disease Carbon Surgery Coronary arteries Stenosis Linear Models biology.protein business |
| Zdroj: | Angiology. 53:563-568 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331970205300510 |
| Popis: | The aim of this study was to investigate the effects of stent carbon coating on inflammatory response. The authors serially measured plasma concentrations of C-reactive protein (CRP), fibrinogen, and several cytokines (tumor necrosis factor, interleukin [IL]-1-β, IL-6, and IL-8) in patients with single-vessel coronary stenosis who underwent primary stent implantation. None of the subjects had inflammatory or infectious disease at the time of the procedure. Forty-six patients (38 males; mean age 55 ±9 years) were studied. Blood samples were collected before and at 2, 4, 6, 24, and 48 hours after stent implantation. Patients were randomly assigned 1 of 2 different stent types, an uncoated MAC (AMG® Raesfeld-Erle, Germany) (UC-MAC) or a carbon-coated MAC (CC-MAC) stent. Implantations were performed without predilatation, and stents were deployed at a maximum pressure of 6 atmospheres for 90 seconds. Of the 46 patients, 14 had stable, 27 had unstable, and 5 had atypical angina. According to ACC/AHA classification, 35 lesions (76.1 %) were type A, 10 (21.7%) were type B, and 1 (2.2%) was type C. Single stenosis of 28 left anterior descending, 12 circumflex, and 6 right coronary arteries were treated. Serum IL-6 increased in both the UC-MAC and CC-MAC groups, with concentra tions significantly elevated above baseline at 6 hours, and then decreasing after 24 hours (baseline, 6-hour, and 24-hour values = 3.1 ±2.3, 5.7 ±3.8, and 6.3 ±4.6 pg/mL, respectively, in UC-MAC; 3.7 ±2.6, 6.2 ±6.0, and 4.6 ±3.7 pg/mL, respectively, in CC-MAC [p=0.002]). Plasma fibrinogen, CRP, and leukocyte concentrations also increased in both groups over the 24 hours (p < 0.05). The elevations of IL-6, CRP, and fibrinogen were similar in the 2 groups. The percent increases in IL-6, fibrinogen, and CRP were not associated with stent length, size, or clinical presentation (all p>0.05). The results showed that stent implantation increases plasma IL-6, fibrinogen, and CRP concentrations, but carbon coating of the stent does not seem to affect this inflammatory response. |
| Databáze: | OpenAIRE |
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