Epidemiology of 2009 pandemic influenza A virus subtype H1N1 among Kenyans aged 2 months to 18 years, 2009-2010
| Autor: | Jane Barani, Julia Wangui, Karen K. Wong, David Schnabel, Josephat Mwangi, Sandra Schwarcz, Wallace D. Bulimo, Beryl D. Obura, Rachel Achilla, Japhet Magana, Finley Osuna, K. Mitei, Janet Majanja, Meshack Wadegu, Benjamin Opot, Samwel Lifumo, S Mukunzi, J. Njiri, Maylor Simwa, J. Muthoni |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Bodily Secretions Time Factors Adolescent viruses Orthomyxoviridae Population Respiratory System medicine.disease_cause Virus Age Distribution Influenza A Virus H1N1 Subtype Internal medicine Epidemiology Pandemic Influenza Human medicine Influenza A virus Prevalence Immunology and Allergy Humans education Child education.field_of_study biology business.industry virus diseases Infant biology.organism_classification Virology Kenya Influenza A virus subtype H5N1 respiratory tract diseases Infectious Diseases Child Preschool Human mortality from H5N1 Female Topography Medical business |
| Zdroj: | The Journal of infectious diseases. 206 |
| ISSN: | 1537-6613 |
| Popis: | Background The US Army Medical Research Unit-Kenya (USAMRU-K) conducts surveillance for influenza-like illness (ILI) in Kenya. We describe the temporal and geographic progression of A(H1N1)pdm09 as it emerged in Kenya and characterize the outpatient population with A(H1N1)pdm09 infection. Methods We included patients with ILI aged 2 months to 18 years enrolled during June 2009-August 2010. Respiratory specimens were tested by real-time reverse-transcription polymerase chain reaction for influenza virus. Patients with A(H1N1)pdm09 infection were compared to those with seasonal influenza A virus infection and those with ILI who had no virus or a virus other than influenza virus identified (hereafter, "noninfluenza ILI"). Results Of 4251 patients with ILI, 193 had laboratory-confirmed A(H1N1)pdm09 infection. The first pandemic influenza case detected by USAMRU-K surveillance was in August 2009; peak activity nationwide occurred during October-November 2009. Patients with A(H1N1)pdm09 infection were more likely to be school-aged, compared with patients with seasonal influenza A virus infection (prevalence ratio [PR], 2.0; 95% confidence interval [CI], 1.3-3.1) or noninfluenza ILI (PR, 3.2; 95% CI, 2.4-4.3). Conclusions USAMRU-K ILI surveillance detected the geographic and temporal distribution of pandemic influenza in Kenya. The age distribution of A(H1N1)pdm09 infections included more school-aged children, compared with seasonal influenza A virus infection and noninfluenza ILI. |
| Databáze: | OpenAIRE |
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