The Potential of Utilizing Mid-Energy X-Rays for In-Line Phase Sensitive Breast Cancer Imaging
| Autor: | Aimin Yan, Muhammad U. Ghani, Yuhua Li, Hong Liu, Peter Jenkins, Bin Zheng, Xizeng Wu, Farid H. Omoumi, Molly D. Wong |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Physics
medicine.diagnostic_test Image quality business.industry Phase-contrast X-ray imaging Edge enhancement Imaging phantom Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Contrast-to-noise ratio 030220 oncology & carcinogenesis medicine Mammography Figure of merit Radiology Nuclear Medicine and imaging Phase retrieval Nuclear medicine business |
| Zdroj: | Biomed Spectrosc Imaging |
| Popis: | OBJECTIVE: The objective of this phantom study is to demonstrate the potential of utilizing mid-energy x-rays for in-line phase-sensitive breast cancer imaging by phantom studies. METHODS: The midenergy (50–80 kV) in-line phase sensitive imaging prototype was used to acquire images of the contrast-detail mammography (CDMAM) phantom, an ACR accreditation phantom, and an acrylic edge phantom. The low-dose mid-energy phase-sensitive images were acquired at 60 kV with a radiation dose of 0.9 mGy, while the high-energy phase-sensitive images were acquired at 90 kV with a radiation dose of 1.2 mGy. The Phase-Attenuation Duality (PAD) principle for soft tissue was used for the phase retrieval. A blind observer study was conducted and paired-sample T-test were performed to compare the mean differences in the two imaging systems. RESULTS: The correct detection ratio for the CDMAM phantom for phase-contrast images acquired by the low-dose mid-energy system was 56.91%, whereas images acquired by the high-energy system correctly revealed only 40.97% of discs. The correct detection ratios were 57.88% and 43.41% for phase-retrieved images acquired by the low-dose mid-energy and high-energy imaging systems, respectively. The reading scores for all three groups of objects in the ACR phantom were higher for the mid energy imaging system as compared to the high-energy system for both phase-contrast and phase-retrieved images. The calculated edge enhancement index (EEI) from the acrylic edge phantom image for the mid-energy system was higher than that calculated for the high-energy imaging system. The quantitative analyses showed a higher Contrast to Noise Ratio (CNR) as well as a higher Figure of Merit (FOM) in images acquired by the low-dose mid-energy imaging system. CONCLUSION: The PAD based retrieval method can be applied in mid-energy system without remarkably affecting the image quality, and in fact, it improves the lesion detectability with a patient dose saving of 25%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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