Longitudinal melanonychia on multiple nails induced by hydroxyurea
| Autor: | Anh Ly Nguyen, Chantal C W Theunissen, John E M Körver |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Polycythaemia
medicine.medical_specialty Antineoplastic Agents Pigmentations Article Nail Diseases 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine Humans Hydroxyurea Outpatient clinic Medical history Family history Polycythemia Vera Aged integumentary system business.industry General Medicine medicine.disease Dermatology medicine.anatomical_structure 030220 oncology & carcinogenesis Nail (anatomy) Terbinafine Subungual hyperkeratosis Female business Pigmentation Disorders medicine.drug |
| Zdroj: | BMJ Case Reports. :bcr2016218644 |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2016-218644 |
| Popis: | A Caucasian woman aged 67 years presented to our outpatient clinic with an 18 months history of asymptomatic continuously progressing longitudinal brown bands on her toenails. There was no history of trauma or friction to her toenails. She was ineffectively treated with oral terbinafine for 3 months due to suspected onychomycosis. Since 3 years, she received treatment for polycythaemia vera with hydroxyurea in varying doses ranging from 500 to 1500 mg daily. Her polycythaemia vera was adequately regulated. She experienced no other side effects. Her medical history was otherwise unremarkable. Family history was negative for longitudinal melanonychia and melanoma. Physical examination showed multiple longitudinal brown-pigmented bands on eight toenails with subungual hyperkeratosis. Pseudo-Hutchinson's sign was present as the pigmentations extended proximally beneath the translucent cuticles, but the cuticles and nail folds were not affected (figures 1 and 2A). Her fingernails … |
| Databáze: | OpenAIRE |
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