Two-dimensional infrared spectroscopy: an emerging analytical tool?
| Autor: | Neil T. Hunt, Samantha Hume, Lucy Minnes, Robby Fritzsch, Glenn A. Burley, Matthew J. Baker |
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| Rok vydání: | 2020 |
| Předmět: |
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Molecular Spectrophotometry Infrared Protein Conformation Infrared spectroscopy 02 engineering and technology Biomolecular structure 010402 general chemistry 01 natural sciences Biochemistry Analytical Chemistry Laser technology Still face Electrochemistry Environmental Chemistry Animals Humans QD Spectroscopy QC Physics Proteins Equipment Design 021001 nanoscience & nanotechnology Molecular science 0104 chemical sciences Two-dimensional infrared spectroscopy Data analysis Systems engineering 0210 nano-technology |
| Zdroj: | The Analyst. 145(6) |
| ISSN: | 1364-5528 0003-2654 |
| Popis: | Ultrafast two-dimensional infrared (2D-IR) spectroscopy has provided valuable insights into biomolecular structure and dynamics, but recent progress in laser technology and data analysis methods have demonstrated the potential for high throughput 2D-IR measurements and analytical applications. Using 2D-IR as an analytical tool requires a different approach to data collection and analysis compared to pure research applications however and, in this review, we highlight progress towards usage of 2D-IR spectroscopy in areas relevant to biomedical, pharmaceutical and analytical molecular science. We summarise the technical and methodological advances made to date and discuss the challenges that still face 2D-IR spectroscopy as it attempts to transition from the state-of-the-art laser laboratory to the standard suite of analytical tools. |
| Databáze: | OpenAIRE |
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