Atropine- and tetrodotoxin-resistant motor activity, responsive to 4-aminopyridine, present in isolated rabbit jejunum
| Autor: | Diego R. Gonzalez, Antonio Morales-Aguilera |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Atropine
Male Drug Resistance Aminopyridines Tetrodotoxin Pharmacology Biology In Vitro Techniques Synaptic Transmission Jejunum medicine Animals 4-Aminopyridine Lagomorpha Biological activity Muscle Smooth biology.organism_classification medicine.anatomical_structure Biochemistry Excitatory postsynaptic potential Cholinergic Rabbits Acetylcholine medicine.drug Muscle Contraction |
| Zdroj: | European journal of pharmacology. 114(3) |
| ISSN: | 0014-2999 |
| Popis: | The effects of 4-aminopyridine on the spontaneous contractile activity of rabbi jejunum segments were studied. Apart from its effects on the cholinergic component of the spontaneous activity, the drug was found to be effective to increase an atropine-, tetrodotoxin-resistant activity of the preparation, suggesting either a direct effect on intestinal smooth muscle cells or an indirect effect through an unidentified excitatory innervation. |
| Databáze: | OpenAIRE |
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