Left egocentric neglect in early subacute right-stroke patients is related to damage of the superior longitudinal fasciculus
| Autor: | Valerio Santangelo, Giovanni Giulietti, Carlo Caltagirone, Maria Antonietta De Luca, Alessandro Matano, Claudia Marzi, Rita Vadalà, Barbara Spanò, Chiara Briani, Ilenia Salsano, Davide Nardo |
|---|---|
| Přispěvatelé: | Spanò, Barbara [0000-0002-5291-0984], Apollo - University of Cambridge Repository, Spanò, Barbara, Nardo, Davide, Giulietti, Giovanni, Matano, Alessandro, Salsano, Ilenia, Briani, Chiara, Vadalà, Rita, Marzi, Claudia, De Luca, Maria, Caltagirone, Carlo, Santangelo, Valerio |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience media_common.quotation_subject Allocentric neglect egocentric allocentric Neuroimaging Neuropsychological Tests computer.software_genre 050105 experimental psychology Functional Laterality Neglect White matter Perceptual Disorders 03 medical and health sciences Behavioral Neuroscience Cellular and Molecular Neuroscience 0302 clinical medicine Physical medicine and rehabilitation Voxel medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Association (psychology) Stroke media_common VLSM 05 social sciences Superior longitudinal fasciculus Neuropsychology medicine.disease Magnetic Resonance Imaging White Matter Psychiatry and Mental health medicine.anatomical_structure Neurology Space Perception Neuropsychological Test Egocentric Neurology (clinical) Perceptual Disorder Psychology computer 030217 neurology & neurosurgery Human |
| Popis: | A typical consequence of stroke in the right hemisphere is unilateral spatial neglect. Distinct forms of neglect have been described, such as space-based (egocentric) and object-based (allocentric) neglect. However, the relationship between these two forms of neglect is still far from being understood, as well as their neural substrates. Here, we further explore this issue by using voxel lesion symptoms mapping (VLSM) analyses on a large sample of early subacute right-stroke patients assessed with the Apples Cancellation Test. This is a sensitive test that simultaneously measures both egocentric and allocentric neglect. Behaviourally, we found no correlation between egocentric and allocentric performance, indicating independent mechanisms supporting the two forms of neglect. This was confirmed by the VLSM analysis that pointed out a link between a damage in the superior longitudinal fasciculus and left egocentric neglect. By contrast, no association was found between brain damage and left allocentric neglect. These results indicate a higher probability to observe egocentric neglect as a consequence of white matter damages in the superior longitudinal fasciculus, while allocentric neglect appears more “globally” related to the whole lesion map. Overall, these findings on early subacute right-stroke patients highlight the role played by white matter integrity in sustaining attention-related operations within an egocentric frame of reference. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|