Endogenous Opioid System during Inspiratory Loading in Patients with Type I Diabetes
| Autor: | Martin Auinger, Karl Irsigler, Heinz Lahrmann, Emil Ogris, Hartmut Zwick, Monika Merkle, Theodor Wanke, Dieter Formanek |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Respiratory rate Esophagus Internal medicine Diabetes mellitus Pressure medicine Humans In patient Tidal volume Endogenous opioid business.industry Airway Resistance Respiration beta-Endorphin Inspiratory muscle medicine.disease Respiratory Muscles Diabetes Mellitus Type 1 Physical Endurance Respiratory Mechanics Cardiology Breathing Physical therapy Type i diabetes Female business |
| Zdroj: | American Review of Respiratory Disease. 148:1335-1340 |
| ISSN: | 0003-0805 |
| DOI: | 10.1164/ajrccm/148.5.1335 |
| Popis: | To investigate the activity of the endogenous opioid system in patients with insulin-dependent diabetes mellitus during ventilatory stress situations, we measured plasma beta-endorphin levels in six male and five female diabetic patients breathing against fatiguing inspiratory resistive loads. The patients had to generate with each inspiration an esophageal pressure (Pes) 80% of maximum until they were exhausted and could no longer develop target Pes. The loaded breathing run was repeated three times with a 1-min interval between each run. Duty cycle, tidal volume, and breathing frequency were constant in all tasks. For each run plasma beta-endorphin levels were measured, inspiratory effort sensation assessed using a modified Borg scale, and inspiratory muscle endurance evaluated by the length of time the task could be maintained (Tlim). A group of 11 sex-, age-, height-, and weight-matched healthy individuals served as control subjects. Tlim was significantly lower in the diabetic patients. Evaluating respiratory effort during the three test runs in control subjects at a time corresponding to the break point of loaded breathing in patients showed significantly lower Borg ratings in the control group than in the patient group. Baseline plasma beta-endorphin was significantly lower in the diabetic patients (10.6 +/- 2.1 versus 27.0 +/- 4.2 pg/ml, p0.01). Additionally, whereas resistive loaded breathing caused a further increase in plasma beta-endorphin concentration in the control group (p0.005), absolutely no increase was found in the diabetic patients. We conclude that the endogenous opioid system in insulin-dependent diabetic patients does not respond to stress caused by breathing against fatiguing inspiratory resistive loads. |
| Databáze: | OpenAIRE |
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