Establishment of a Gonococcal Antimicrobial Surveillance Programme, in Accordance With World Health Organization Standards, in Côte d'Ivoire, Western Africa, 2014–2017
| Autor: | Teodora Wi, Francis Bazan, Belinda Kouamé-Blavo, Alain Yeo, Clarisse E Kouamé, Ahou C Yao, Magnus Unemo, Hortense Faye-Kette, Brigitte D Gbedé, Abdoulaye Ouattara, Mireille Dosso |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Microbiology (medical) Sexually transmitted disease medicine.medical_specialty Adolescent Gonorrhea Microbial Sensitivity Tests Dermatology Drug resistance Azithromycin World Health Organization medicine.disease_cause Young Adult 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Ciprofloxacin Drug Resistance Multiple Bacterial Internal medicine Prevalence medicine Humans Treatment Failure 030212 general & internal medicine Etest 030505 public health business.industry Public Health Environmental and Occupational Health Middle Aged medicine.disease Neisseria gonorrhoeae Anti-Bacterial Agents Cote d'Ivoire Infectious Diseases Female 0305 other medical science business Sentinel Surveillance Cefixime medicine.drug |
| Zdroj: | Sexually Transmitted Diseases. 46:179-184 |
| ISSN: | 1537-4521 0148-5717 |
| DOI: | 10.1097/olq.0000000000000943 |
| Popis: | Background Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is compromising the treatment of gonorrhea globally. Recent AMR data are extremely limited in Africa, and mainly totally lacking in Western Africa, including Cote d'Ivoire. This study (i) established a quality-assured gonococcal antimicrobial surveillance program, according to World Health Organization quality criteria, (ii) investigated the AMR to 8 therapeutic antimicrobials in gonococcal isolates from 2014 to 2017, and (iii) provided evidence for updating the National Sexually Transmitted Disease Syndromic Management Guidelines in Cote d'Ivoire. Methods During 2014 to 2017, gonococcal isolates were obtained from sexually active symptomatic or asymptomatic males and females in 14 sites in Cote d'Ivoire. It was a special focus on symptomatic males, and their sexual partners, due to the higher culture positivity rates in symptomatic males. Patient metadata were collected, including age, gender, sexual orientation, and symptoms. Minimum inhibitory concentrations of 8 antimicrobials were determined by Etest and interpreted using European Committee on Antimicrobial Susceptibility Testing breakpoints. β-lactamase production was detected using cefinase disks. Results The level of resistance, examining 212 gonococcal isolates, was as follows: 84.9% to tetracycline, 68.9% to benzylpenicillin, 62.7% to ciprofloxacin, 6.1% to azithromycin, and 1.4% to gentamicin. All isolates were susceptible to ceftriaxone, cefixime and spectinomycin. Conclusions We provide the first gonococcal AMR data, quality assured according to World Health Organization standards, from Cote d'Ivoire since more than 20 years. The high ciprofloxacin resistance, which informed a revision of the national syndromic management guideline during study, and relatively high resistance to azithromycin demand an improved gonococcal antimicrobial surveillance program and increased awareness when prescribing treatment in Cote d'Ivoire. |
| Databáze: | OpenAIRE |
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