Respiratory effects of normobaric oxygen toxicity in awake guinea-pig
| Autor: | Monique Brun-Pascaud, Jean-Jacques Pocidalo, M.C. Blayo, E Azoulay-Dupuis |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Physiology Guinea Pigs Pulmonary Edema Biology Biochemistry Guinea pig medicine Animals Respiratory system Lung Molecular Biology Oxygen toxicity Acid-Base Equilibrium Asphyxia Respiration General Medicine Pulmonary edema medicine.disease Oxygen medicine.anatomical_structure Anesthesia Toxicity Breathing Acidosis Respiratory medicine.symptom |
| Zdroj: | Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 74:831-836 |
| ISSN: | 0305-0491 |
| Popis: | 1. We studied the time course of the respiratory events in awake guinea-pigs catheterized with a chronic arterial cannula, exposed to 100% O 2 during 48 hr and after air return breathing. 2. 2. The oxygen toxicity has a pulmonary and respiratory expression: clinical, histological and biochemical data show that death is related to the asphyxia generated by acute pulmonary edema. 3. 3. The O 2 toxicity respiratory effects show striking differences in rats and guinea-pigs; the differences belong to a specific and particular lymphatic system in the rat. 4. 4. Rat and guinea pig offer two different models of pulmonary edema, (the first is characterized by absence of arterial hypoxemia) and in consequence two different models of lung oxygen toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|