Pharmacological response to cimetidine and healing of duodenal ulceration: effects of highdose cimetidine and combination of cimetidine with pirenzepine
| Autor: | M. Deakin, J. G. Williams, D. G. Colin-Jones |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Gastroenterology Pharmacotherapy Duodenitis Duodenal ulceration Internal medicine medicine Humans Pharmacology (medical) In patient Erosive duodenitis Cimetidine Aged Hepatology business.industry Pirenzepine Middle Aged medicine.disease digestive system diseases Gastric secretion Endocrinology Duodenal Ulcer Drug Therapy Combination business medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 2:83-91 |
| ISSN: | 1365-2036 0269-2813 |
| Popis: | Overnight gastric secretion was studied in 32 patients with acute duodenal ulcers before treatment and whilst taking cimetidine 400 mg b.d. After 6 weeks of treatment with cimetidine 400 mg b.d. 13 patients had healed ulcers, seven patients had healed ulcers but a persistent erosive duodenitis, and 12 patients had persisting ulceration. Inhibition of nocturnal gastric secretion by cimetidine 400 mg b.d. was most profound in patients who healed their ulcers completely; a less profound inhibition of nocturnal gastric secretion was seen in the non-healing and duodenitis groups. In patients with persisting ulcers and poor inhibition of nocturnal gastric secretion by cimetidine, gastric secretion could be suppressed by either cimetidine 400 mg b.d. in combination with pirenzepine 50 mg b.d., or by cimetidine 1600 mg nocte, but suppression of nocturnal gastric secretion was more effective with cimetidine 1600 mg than cimetidine with pirenzepine. |
| Databáze: | OpenAIRE |
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