Effects of misoprostol on lipoprotein (a) levels of ovariectomized rats
| Autor: | C.James Chuong, Deborah Lurie, Ali S Sonmez, Mustafa Birincioglu, Yusuf Turkoz, Bahattin Adam |
|---|---|
| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 1999 |
| Předmět: |
Plasma lipoprotein
medicine.medical_specialty Ovariectomy Rats Sprague-Dawley Oral administration Internal medicine Animals ovariectomized rat Medicine Prospective cohort study Misoprostol misoprostol biology business.industry lipoprotein (a) Obstetrics and Gynecology Lipoprotein(a) Rats Endocrinology Reproductive Medicine Ovariectomized rat biology.protein Female business After treatment Lipoprotein medicine.drug |
| Zdroj: | Fertility and Sterility. 72:518-521 |
| ISSN: | 0015-0282 |
| Popis: | WOS: 000082365600023 PubMed: 10519627 Objective: To determine the effects of misoprostol on plasma lipoprotein (a) concentrations of ovariectomized rats. Design: Controlled prospective study. Setting: Animal research laboratory. Animal(s): Four-month-old female Sprague-Dawley rats. Intervention(s): Blood samples were obtained before and 60 days after ovariectomy, and the rats were divided into three groups. Group I (five rats) was treated with vehicle (water); groups II and III (nine and eight rats, respectively) were treated with oral misoprostol at 100 and 200 mu g/kg/d, respectively, for 60 days, after which blood was drawn again. Main Outcome Measure(s): Serum lipoprotein (a) levels. Result(s): The median lipoprotein (a) level before ovariectomy was 10.8 mg/dL (range, 10.6-46.5 mg/dL). Sixty days after ovariectomy, the level increased significantly to 15.9 mg/dL (range, 10.6-36.9 mg/dL). After treatment, there was no change in lipoprotein (a) levels in the vehicle-treated group (range, 16.3-21.1 mg/dL); however, the lipoprotein (a) levels decreased significantly in the group treated with 100 mu g/kg/d of misoprostol, from 15.4 mg/dL to 10.8 mg/dL, and in the group treated with 200 mu g/kg/d of misoprostol, from 17.1 mg/dL to 10.6 mg/dL. Conclusion(s): Misoprostol caused a significant decrease in lipoprotein (a) levels. (Fertil Steril(R) 1999;72: 518-21. (C) 1999 by American Society for Reproductive Medicine.) 518. |
| Databáze: | OpenAIRE |
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