Automatic landmark generation for deformable image registration evaluation for 4D CT images of lung
| Autor: | Jerry J. Battista, Rob Barnett, Jason Vickress, J Morgan, Slav Yartsev |
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| Rok vydání: | 2016 |
| Předmět: |
Landmark
Radiological and Ultrasound Technology business.industry Computer science Respiration Image registration Scale-invariant feature transform 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Medical imaging Humans Radiology Nuclear Medicine and imaging Computer vision Tomography Artificial intelligence Four-Dimensional Computed Tomography business Lung |
| Zdroj: | Physics in medicine and biology. 61(20) |
| ISSN: | 1361-6560 |
| Popis: | Deformable image registration (DIR) has become a common tool in medical imaging across both diagnostic and treatment specialties, but the methods used offer varying levels of accuracy. Evaluation of DIR is commonly performed using manually selected landmarks, which is subjective, tedious and time consuming. We propose a semi-automated method that saves time and provides accuracy comparable to manual selection. Three landmarking methods including manual (with two independent observers), scale invariant feature transform (SIFT), and SIFT with manual editing (SIFT-M) were tested on 10 thoracic 4DCT image studies corresponding to the 0% and 50% phases of respiration. Results of each method were evaluated against a gold standard (GS) landmark set comparing both mean and proximal landmark displacements. The proximal method compares the local deformation magnitude between a test landmark pair and the closest GS pair. Statistical analysis was done using an intra class correlation (ICC) between test and GS displacement values. The creation time per landmark pair was 22, 34, 2.3, and 4.3 s for observers 1 and 2, SIFT, and SIFT-M methods respectively. Across 20 lungs from the 10 CT studies, the ICC values between the GS and observer 1 and 2, SIFT, and SIFT-M methods were 0.85, 0.85, 0.84, and 0.82 for mean lung deformation, and 0.97, 0.98, 0.91, and 0.96 for proximal landmark deformation, respectively. SIFT and SIFT-M methods have an accuracy that is comparable to manual methods when tested against a GS landmark set while saving 90% of the time. The number and distribution of landmarks significantly affected the analysis as manifested by the different results for mean deformation and proximal landmark deformation methods. Automatic landmark methods offer a promising alternative to manual landmarking, if the quantity, quality and distribution of landmarks can be optimized for the intended application. |
| Databáze: | OpenAIRE |
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