Apo material as a trigger for inflammation in systemic lupus erythematosus

Autor:	Norbert Blank, Hanna Marie Meesmann, Marijo Parcina, Martin Schiller, Hanns-Martin Lorenz
Rok vydání:	2009
Předmět:	Immunology Alpha interferon Inflammation Apoptosis medicine.disease_cause Autoimmunity Pathogenesis immune system diseases medicine Immunology and Allergy Animals Humans Lupus Erythematosus Systemic skin and connective tissue diseases Gene Lupus erythematosus business.industry Interferon-alpha Dendritic Cells medicine.disease lipids (amino acids peptides and proteins) medicine.symptom business
Zdroj:	Autoimmunity. 42(4)
ISSN:	1607-842X
Popis:	While several characteristics of systemic lupus erythematosus (SLE) have been investigated, the distinct pathogenetic mechanisms leading to autoimmunity and chronic inflammation are not understood yet. A central role for apo has been implicated in the pathogenesis of SLE and an increased rate of apo or a defective clearance of apo cells have repeatedly been described in SLE patients, which show elevated levels of alpha-interferon (alphaIFN) as well as an enhanced expression of alphaIFN-alpha inducible genes referred to as alphaIFN signature. Recent publications link alphaIFN and apo: apo cell-derived microparticles can directly stimulate plasmacytoid dendritic cells to secret alphaIFN. This review highlights the role of apo material as source for AAg and as a trigger for chronic inflammation in the pathogenesis of SLE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5e0928a7b9cf55da253bb2d04ef3ea https://pubmed.ncbi.nlm.nih.gov/19811267 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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