Characterization of Biomarkers in Polycystic Ovary Syndrome (PCOS) Using Multiple Distinct Proteomic Platforms
| Autor: | Balwir Matharoo-Ball, M Elgasim, Graham Ball, D Tooth, Robert C. Rees, Colin S. Creaser, C Hughes, Robert Layfield, William Atiomo, Lee Lancashire |
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| Rok vydání: | 2007 |
| Předmět: |
Gel electrophoresis
Proteome Polycystic ovary syndrome (PCOS) Haptoglobin General Chemistry Biology medicine.disease Bioinformatics Biochemistry Polycystic ovary Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization medicine biology.protein Humans Electrophoresis Gel Two-Dimensional Female In patient Biomarkers Polycystic Ovary Syndrome |
| Zdroj: | Journal of Proteome Research. 6:3321-3328 |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/pr070124b |
| Popis: | A variety of prefractionation methods (including a novel reversed-phase solid-phase-extraction (RP-SPE) combined with SDS-PAGE and proteomic based approaches (e.g., 2-dimensional gel electrophoresis (2DE) and MALDI-TOF mass spectrometry combined with Artificial Neural Network (ANN) bioinformatic tools) were used to investigate the protein/peptide signatures in patients with Polycystic Ovary Syndrome (PCOS). Four potential PCOS biomarkers were identified (complement C4alpha3c and C4gamma and haptoglobin alpha and beta chains). |
| Databáze: | OpenAIRE |
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