Leprosy presenting as remitting seronegative symmetrical synovitis with pitting oedema syndrome - a case report
| Autor: | Miguel Araújo Abreu, Hugo Morais, Miguel Gomes Guerra, Telma Santos, R. Vieira, Ricardo Jorge Ferreira Taipa, D. Fonseca, Joana Patrícia Abelha Aleixo dos Santos, Sandra Patrícia Abreu Monteiro Pinto, Taciana Videira |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Peripheral neuropathy 030106 microbiology Arthritis Case Report Disease lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Prednisone Synovitis Leprosy Biopsy medicine Edema Humans lcsh:RC109-216 030212 general & internal medicine Mycobacterium leprae Aged Skin medicine.diagnostic_test biology Remitting seronegative symmetrical synovitis with pitting Oedema syndrome business.industry Syndrome medicine.disease biology.organism_classification Dermatology Anti-Bacterial Agents Infectious Diseases business medicine.drug |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP BMC Infectious Diseases BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-5 (2019) |
| Popis: | Background: Leprosy typically manifests with skin and peripheral nerve involvement. Musculoskeletal complaints are the third most common, and can be the sole presenting manifestation. They range from arthralgia/arthritis in reactional states to full mimics of systemic rheumatic diseases. Remitting Seronegative Symmetrical Synovitis with Pitting Oedema syndrome has only been described once in a patient with already diagnosed Leprosy. Case report: A 68-year-old male, from an endemic region of familial amyloid polyneuropathy, presented with an inaugural Remitting Seronegative Symmetrical Synovitis with Pitting Oedema like syndrome, more that 20 years after travelling to Leprosy endemic areas. Arthritis would resurface whenever oral prednisone was tapered, so methotrexate was started, controlling the complaints. Only one year later, after the appearance of peripheral neuropathy and skin lesions, it was possible to diagnose Leprosy, through the identification of Mycobacterium leprae bacilli in a peripheral nerve biopsy. Conclusion: This report is an example of the heterogeneity of manifestations of Leprosy, namely rheumatic, and the challenge of diagnosing it when typical complaints are absent. It is also a reminder that this disease should be considered whenever a patient with a combination of skin/neurologic/rheumatic complaints has travelled to endemic countries in the past. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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