Plasminogen activator inhibitor-1 polymorphisms (-844 GA and HindIII CG) in systemic lupus erythematosus: association with clinical variables
| Autor: | Jorge Ramón Padilla-Gutiérrez, Claudia Azucena Palafox-Sánchez, Yeminia Valle, Gerardo Orozco-Barocio, Edith Oregón-Romero, Mónica Vázquez-Del Mercado, Héctor Rangel-Villalobos, Mara Anaís Llamas-Covarrubias, José Francisco Muñoz-Valle |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent HindIII Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Young Adult Gene Frequency Polymorphism (computer science) Genetic model Genotype Plasminogen Activator Inhibitor 1 medicine Humans Lupus Erythematosus Systemic skin and connective tissue diseases Mexico Aged Lupus erythematosus biology business.industry Haplotype Autoantibody General Medicine Middle Aged medicine.disease chemistry Plasminogen activator inhibitor-1 Case-Control Studies Immunology biology.protein Female business |
| Zdroj: | Clinical and experimental medicine. 11(1) |
| ISSN: | 1591-9528 |
| Popis: | Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the presence of autoantibodies against nuclear autoantigens as well as cytoplasmic and circulating proteins. Recent studies have demonstrated mechanisms responsible for modulation of the immune response by the plasminogen activator inhibitor-1 (PAI-1). Furthermore, the endogenous PAI-1 has shown to promote a Th2 immune response. We assessed the −844 G>A and HindIII C>G PAI-1 polymorphisms in SLE. In a case–control study of 71 SLE patients classified according to ACR criteria and 71 healthy subjects (HS). The A allele of −844 PAI-1 polymorphism showed a significant difference in SLE patients (41%) when compared with HS (27%) [P = 0.01; OR = 1.8, 95%, CI = 1.1–3.0]. In addition, the −844 G>A PAI-1 polymorphism was associated with increased risk for SLE in a dominant genetic model (G/G vs. G/A + A/A; OR = 2.3, 95% CI = 1.14–4.44). Also, anti-RNP positive antibodies in SLE were associated with G/G −844 PAI-1 genotype. The HindIII polymorphism did not show any differences. The haplotype analysis showed that the AC haplotype confers susceptibility to SLE (OR = 3.1, 95% CI, 1.45–6.52; P = 0.003). The AC haplotype of the −844 and HindIII PAI-1 polymorphism might be an additional susceptibility factor to SLE in Mexicans. |
| Databáze: | OpenAIRE |
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