(Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability

Autor: Iraia Muñoa-Hoyos, Itziar Urizar-Arenaza, Zaloa Larreategui, Nicolás Garrido, Jon Irazusta, Nerea Subirán, Marta Gianzo
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Gene Expression
Male infertility
lcsh:Chemistry
0302 clinical medicine
Pregnancy
lcsh:QH301-705.5
Spectroscopy
Sperm motility
reproductive and urinary physiology
media_common
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
Pregnancy Outcome
Embryo
General Medicine
Spermatozoa
Computer Science Applications
Protein Transport
embryonic development
Female
Live Birth
Vacuolar Proton-Translocating ATPases
endocrine system
media_common.quotation_subject
Embryonic Development
Receptors
Cell Surface
Semen
Fertility
Fertilization in Vitro
Semen analysis
Biology
Article
Catalysis
semen analysis
Inorganic Chemistry
Andrology
03 medical and health sciences
medicine
Humans
human
Physical and Theoretical Chemistry
Acrosome
Molecular Biology
Infertility
Male
urogenital system
Organic Chemistry
Embryo Transfer
medicine.disease
Sperm
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
reproductive techniques
prorenin receptor
assisted
Zdroj: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
International Journal of Molecular Sciences
Addi. Archivo Digital para la Docencia y la Investigación
Universidad de Cantabria (UC)
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 3215, p 3215 (2021)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
ISSN: 1422-0067
Popis: Sperm fertility ability may be modulated by different molecular systems, such as the renin-angiotensin system (RAS). Although renin is one of its most relevant peptides, the presence and role of the (pro)renin receptor (PRR) is completely unknown. We have proved for the first time the existence of PRR and its transcript in human sperm by western blot and RT-PCR. Immunofluorescence studies showed that this receptor is mainly located in the apical region over the acrosome and in the postacrosomal region of the sperm head and along the sperm tail. In addition, this prospective cohort study also proves that semen samples with higher percentages of PRR-positive spermatozoa are associated with poor sperm motility, worse blastocyst development and no-viable blastocysts. Our results provide insight into how PRR play a negative role in sperm physiology that it may condition human embryo quality and development. An in-depth understanding of the role of PRR in sperm fertility can help elucidate its role in male infertility, as well as establish biomarkers for the diagnosis or selection of sperm to use during assisted reproductive techniques. This research was funded by grants from the Basque Government (GIC12/173; to M.G. and I.M.-H.) and University of the Basque Country (UPV/EHU; to M.G. and I.U.-A.) (EHUA14/17).
Databáze: OpenAIRE
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