A Case of Pseudo-Bartter's Syndrome Associated with Hypergastrinemia, Thrombocytosis and Increased Serum Thyroxine-Binding Globulin
| Autor: | N. Sekita, Kazuhiko Someya, Kazutoshi Okano, Satoru Naitoh, Yukio Yamada, Makoto Shimizu, Kazuko Sasagawa, Hozumi Isobe, Satoshi Suzuki |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Urinary system Plasma renin activity Thirst Diagnosis Differential Thyroxine-Binding Proteins chemistry.chemical_compound Endocrinology Sex hormone-binding globulin Internal medicine Gastrins Humans Medicine Organic Chemicals Thrombocytosis biology Cathartics business.industry General Engineering Bartter Syndrome Hydrogen-Ion Concentration medicine.disease Bartter's syndrome Blood pressure chemistry biology.protein Spironolactone Female medicine.symptom business |
| Zdroj: | Endocrinologia Japonica. 37:787-796 |
| ISSN: | 2185-6370 0013-7219 |
| DOI: | 10.1507/endocrj1954.37.787 |
| Popis: | A housewife, 40 years of age, was admitted with dysesthesia of the extremities, muscle weakness, and attacks of adynamia and thirst. She had been taking a laxative for more than 20 years. On physical examination, blood pressure was 94/56 mmHg. Laboratory tests revealed thrombocytosis, low serum K and marked increases in both plasma renin activity and serum aldosterone. Serum TBG was increased. Serum gastrin was also markedly increased and could not be enhanced by exogenous secretin. Both angiotensin 11 loading test and noradrenalin loading test failed to increase blood pressure. Ammonium chloride loading to examine the disturbance of urinary acidification was abnormal in the short term test and borderline in the long term test. Following a diagnosis of pseudo-Bartter's syndrome induced by long term intake of laxative and repeated diarrhea, the administration of laxative was interrupted and potassium, indomethacin and spironolactone were administered. However, serum K remained low. Hypergastrinemia, thrombocytosis and a high serum TBG level also persisted, the causes of which remain unknown. This is the first reported case of pseudo-Bartter's syndrome associated with hypergastrinemia, thrombocytosis and increased serum TBG. |
| Databáze: | OpenAIRE |
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