Rostral cingulate gyrus: A putative target for deep brain stimulation in treatment-refractory depression
| Autor: | Damianos E. Sakas, Ioannis G. Panourias |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Obsessive-Compulsive Disorder
Deep brain stimulation Nerve net Deep Brain Stimulation medicine.medical_treatment Models Neurological Disease Gyrus Cinguli Models Biological Neuroimaging Gyrus medicine Biological neural network Humans Depression (differential diagnoses) Neurons Depressive Disorder Treatment refractory Brain Parkinson Disease General Medicine Models Theoretical medicine.anatomical_structure nervous system Nerve Net Psychology Neuroscience |
| Zdroj: | Medical Hypotheses. 66:491-494 |
| ISSN: | 0306-9877 |
| Popis: | Surgery for intractable affective illnesses has generated considerable controversy over the last century. Deep brain stimulation (DBS) has revolutionized neurosurgical practice, especially in the field of advanced Parkinson's disease and, more recently, in selected medical-refractory cases of obsessive-compulsive disorder. In this paper, we propose a discrete area of the rostral cingulate gyrus as a potential target for DBS in medical-resistant depressive patients. Brodmann's area 24a has proved to be a vital link in the integration of neural circuits underlying depression, both through proposed neurobiological models and accurate neuroimaging studies. The full reversibility and adjustability of DBS offer the best chance to treat the multidimensional and life-span profile of depression, so giving hope to a great number of desperate human beings. |
| Databáze: | OpenAIRE |
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