Improvisation and Evaluation of Laterosporulin Coated Titanium Surfaces for dental Applications: An In Vitro Investigation
| Autor: | Vishakha Grover, Suresh Korpole, Rajni Jain, Sumeeta Kumari, Priyanka Chopra, Rup Lal, Komal Sehgal, Manjula Mehta |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0303 health sciences Brevibacillus biology 030306 microbiology Chemistry Antimicrobial peptides Biofilm Streptococcus gordonii chemistry.chemical_element biology.organism_classification Antimicrobial Dental plaque medicine.disease 01 natural sciences Microbiology 03 medical and health sciences stomatognathic diseases 010608 biotechnology medicine Implant Original Research Article Titanium |
| Zdroj: | Indian J Microbiol |
| ISSN: | 0046-8991 |
| Popis: | Despite recent improvement in implant survival rates, there remains a significant demand for enhancing the long-term clinical efficacy of titanium (Ti) implants, particularly for the prevention of peri-implantitis. Bioactive substances such as antimicrobial peptides are emerging as effective alternatives for contemporary antimicrobial agents used in dental health care. Current research work was focused to use laterosporulins that are non-haemolytic cationic antimicrobial peptides from Brevibacillus spp. for coating commercially available Ti discs. The coated Ti surfaces were evaluated in vitro for biofilm formation by two dental plaque isolates Streptococcus gordonii strain DIGK25 and S. mutans strain DIGK119 as representatives of commensal and pathogenic streptococci respectively. The biofilm inhibition was ascertained with replicated experiments on hydroxyapatite discs and confirmed by florescence microscopy. The laterosporulin coated Ti discs showed significantly reduced biofilm formation by oral streptococci and displayed promising potential to enhance the antibacterial surface properties. Such improvised Ti surfaces may curb the menace of oral streptococcal biofilm formation on dental implants and the associated implant failures. |
| Databáze: | OpenAIRE |
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