Quadrivalent influenza nanoparticle vaccines induce broad protection
| Autor: | Masaru Kanekiyo, Lance Stewart, George Ueda, Rashmi Ravichandran, Nick Matheson, Miklos Guttman, Young-Jun Park, David Veesler, John R. Mascola, Syed M. Moin, Adrian Creanga, Barney S. Graham, Daniel Ellis, John R. Vaile, Deleah Pettie, Geoffrey B. Hutchinson, David Baker, Sila Ataca, Lauren Carter, Michael E. P. Murphy, Oliver J. Acton, Rebecca A. Gillespie, Michelle C. Crank, Neil P. King, Seyhan Boyoglu-Barnum, Sally Kephart, Michael J. Watson, Kelly K. Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Models Molecular Subdominant Influenza vaccine Heterologous Hemagglutinin Glycoproteins Influenza Virus Article 03 medical and health sciences Mice 0302 clinical medicine Influenza A Virus H1N1 Subtype Influenza Human Animals Humans chemistry.chemical_classification Mice Inbred BALB C Multidisciplinary biology Influenza A Virus H3N2 Subtype Ferrets virus diseases Virology Disease Models Animal 030104 developmental biology Antibody response Nanomedicine chemistry Influenza A virus Influenza Vaccines biology.protein Nanoparticles Female Protective antibody Antibody Glycoprotein 030217 neurology & neurosurgery Broadly Neutralizing Antibodies |
| Zdroj: | Nature |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immunization1. Here we show that computationally designed, two-component nanoparticle immunogens2 induce potently neutralizing and broadly protective antibody responses against a wide variety of influenza viruses. The nanoparticle immunogens contain 20 haemagglutinin glycoprotein trimers in an ordered array, and their assembly in vitro enables the precisely controlled co-display of multiple distinct haemagglutinin proteins in defined ratios. Nanoparticle immunogens that co-display the four haemagglutinins of licensed quadrivalent influenza vaccines elicited antibody responses in several animal models against vaccine-matched strains that were equivalent to or better than commercial quadrivalent influenza vaccines, and simultaneously induced broadly protective antibody responses to heterologous viruses by targeting the subdominant yet conserved haemagglutinin stem. The combination of potent receptor-blocking and cross-reactive stem-directed antibodies induced by the nanoparticle immunogens makes them attractive candidates for a supraseasonal influenza vaccine candidate with the potential to replace conventional seasonal vaccines3. A nanoparticle influenza vaccine candidate is shown to induce broad cross-reactive antibody responses in animal models. |
| Databáze: | OpenAIRE |
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