Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata
| Autor: | Maria B. Cassera, Priscilla Krai, Michael Goetz, Qingxi Su, David G. I. Kingston |
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| Rok vydání: | 2015 |
| Předmět: |
Pterocarpans
Stereochemistry Plasmodium falciparum Apoplanesia paniculata Pharmaceutical Science Fractionation Plant Roots Article Analytical Chemistry Antimalarials Cell Line Tumor Drug Discovery Humans Pharmacology Amorphaquinone Molecular Structure Plant Extracts Chemistry Organic Chemistry Quinones Fabaceae Isoflavones Complementary and alternative medicine Molecular Medicine Female |
| Zdroj: | Planta Medica. 81:1128-1132 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone ( 1 ), pendulone ( 2 ), and melilotocarpan C ( 3 ), and the two new pterocarpans 4 and 5 . Compounds 1 and 2 exhibited good antiplasmodial activity with IC 50 values of 5.7 ± 1.5 and 7.0 ± 0.8 µM, respectively. Compound 3 exhibited weak antiplasmodial activity (41.8 ± 5.2 µM), while compounds 4 and 5 were inactive. Compound 6 was synthesized to confirm the structure of 5 , and it showed enhanced antiplasmodial activity (15.8 ± 1.4 µM) compared to its analogues 3 – 5 . |
| Databáze: | OpenAIRE |
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