Role of glucagon in disposal of an amino acid load
| Autor: | Luc Tappy, I Rezvani, Robert D. Hoeldtke, O E Owen, G. Boden, F. Jadali |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Biology Fatty Acids Nonesterified Glucagon chemistry.chemical_compound Physiology (medical) Internal medicine medicine Humans Insulin Amino Acids Pancreatic hormone chemistry.chemical_classification Metabolism Glucose clamp technique Recombinant Proteins Amino acid Kinetics Endocrinology Somatostatin Glucose chemistry Liver Growth Hormone Urea Glucose Clamp Technique hormones hormone substitutes and hormone antagonists Hyperglucagonemia |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0002-9513 |
| Popis: | Amino acids stimulate the release of glucagon and insulin. To assess the role of aminogenic hyperglucagonemia, we have studied, in healthy young males, the effects of basal (less than 100 pg/ml) and high (200-400 pg/ml) plasma glucagon concentrations on amino acid metabolism during intravenous infusion (0.5 g.h-1.4 h) of a mixture of 15 amino acids. Basal plasma glucagon concentrations were obtained by infusion of somatostatin (0.5 mg/h) plus glucagon (0.25 ng.kg-1.min-1) and high plasma glucagon concentrations by infusion of somatostatin plus glucagon (3.0 ng.kg-1.min-1) or by infusion of amino acids alone. All studies were performed under conditions of euglycemic (83-91 mg/dl) hyperinsulinemia (50-80 microU/ml). Hyperglucagonemia significantly increased 1) net amino acid transport from the extracellular into the intracellular space (by approximately 4%), 2) net degradation of amino acids entering the intracellular space (by approximately 40%), and 3) conversion of degraded amino acids into glucose from 0-10% (basal glucagon) to 70-100% (high glucagon). Hyperglucagonemia did not affect the amount of amino acids excreted in the urine (approximately 4%). We conclude that glucagon plays an important role in the disposition of amino acids by increasing their inward transport, their degradation, and their conversion into glucose. |
| Databáze: | OpenAIRE |
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