The influence of antimicrobial peptides and mucolytics on the integrity of biofilms consisting of bacteria and yeasts as affecting voice prosthetic air flow resistance
| Autor: | Henny C. van der Mei, Ranny van Weissenbruch, Henk J. Busscher, Frans W. J. Albers, Janine J. H. Oosterhof, G. Jolanda Elving, Arie Van Nieuw Amerongen, Ietse Stokroos |
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| Přispěvatelé: | Orale Biochemie (OUD, ACTA), Faculteit Medische Wetenschappen/UMCG, Man, Biomaterials and Microbes (MBM), Personalized Healthcare Technology (PHT) |
| Rok vydání: | 2003 |
| Předmět: |
Models
Anatomic Antimicrobial peptides Colony Count Microbial Aquatic Science Biology TRICLOSAN Applied Microbiology and Biotechnology biofilm Microbiology chemistry.chemical_compound Extracellular polymeric substance DECONTAMINATION TUBES Yeasts medicine extracellular polymeric substances Humans Water Science and Technology Expectorants Bacteria voice prosthesis Airway Resistance Chlorhexidine Biofilm Saliva Artificial biochemical phenomena metabolism and nutrition synthetic salivary peptides N-ACETYLCYSTEINE Ascorbic acid Voice prosthesis Antimicrobial Triclosan Acetylcysteine chemistry Biofilms Anti-Infective Agents Local Microscopy Electron Scanning ascorbic acid HEALTH Larynx Artificial medicine.drug |
| Zdroj: | BIOFOULING, 19, 347-353. Taylor and Francis Ltd. Biofouling, 19(6), 347-353. TAYLOR & FRANCIS LTD Oosterhof, J J H, Elving, G J, Stokroos, I, van Nieuw Amerongen, A, van der Mei, H C, Busscher, H J, van Weissenbruch, R & Albers, F W J 2003, ' The influence of antimicrobial peptides and mucolytics on the integrity of biofilms consisting of bacteria and yeasts as affecting voice prosthetic air flow resistance ', BIOFOULING, vol. 19, pp. 347-353 . https://doi.org/10.1080/08927010310001612054 |
| ISSN: | 0892-7014 |
| DOI: | 10.1080/08927010310001612054 |
| Popis: | The integrity of biofilms on voice prostheses used to rehabilitate speech in laryngectomized patients causes unwanted increases in airflow resistance, impeding speech. Biofilm integrity is ensured by extracellular polymeric substances (EPS). This study aimed to determine whether synthetic salivary peptides or mucolytics, including N-acetylcysteine and ascorbic acid, influence the integrity of voice prosthetic biofilms. Biofilms were grown on voice prostheses in an artificial throat model and exposed to synthetic salivary peptides, mucolytics and two different antiseptics (chlorhexidine and Triclosan). Synthetic salivary peptides did not reduce the air flow resistance of voice prostheses after biofilm formation. Although both chlorhexidine and Triclosan reduced microbial numbers on the prostheses, only the Triclosan-containing positive control reduced the air flow resistance. Unlike ascorbic acid, the mucolytic N-acetylcysteine removed most EPS from the biofilms and induced a decrease in air flow resistance. |
| Databáze: | OpenAIRE |
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