Clustering of chronic kidney disease and cardiovascular risk factors in South-West Nigeria
| Autor: | A Akinsola, Olugbenga E. Ayodele, Rotimi Oluyombo, P.O. Akinwusi, Michael Adeyemi Olamoyegun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Population 030232 urology & nephrology Renal function 030204 cardiovascular system & hematology Clustering 03 medical and health sciences 0302 clinical medicine Internal medicine Chronic kidney disease Medicine education Cardiovascular risk factors Univariate analysis education.field_of_study Proteinuria business.industry medicine.disease Endocrinology Blood pressure Nephrology Albuminuria Microalbuminuria Original Article medicine.symptom business Kidney disease |
| Zdroj: | Journal of Nephropathology |
| ISSN: | 2251-8819 2251-8363 |
| Popis: | Background: There exists a synergy between chronic kidney disease (CKD) and cardiovascular risk factors (CVRFs) with increased morbidity and poor outcomes. Objectives: Data relating to this clustering in black homogenous populations is scanty. We aim to investigate this relationship in Nigerian communities. Patients and Methods: It was a cross-sectional observation study from semi-urban communities in South-West Nigeria. We used modified World Health Organization (WHO) questionnaire on chronic diseases (WHO STEPS) to gather information on socio-demographic data, biophysical and clinical characteristics. Biochemical analysis of plasma samples was done. Results: We analyzed data of 1084 with mean age of 56.3 ± 19.9 years (33.4% female). Prevalence of stage 3 CKD was 14.2% (3a and 3b were 10.3% and 3% respectively). Prevalence of hypertension (systolic and diastolic blood pressure) and low high-density lipoprotein cholesterol (HDL-C) increased as clustering of cardiovascular (CV) risk factors (CVFRs) increased both in CKD and proteinuria (P < 0.05). CKD prevalence increases with number of risk factors. There was an inverse relationship between increasing risk factors and mean estimated glomerular filtration rate (eGFR) (P < 0.05). Clustering at least 2 CVRFs in the population with CKD compared to those without CKD was significantly higher (76.6% vs. 65.1%, OR: 1.8, 95% CI: 1.2-2.6, P = 0.005). Similarly, in a univariate analysis, albuminuria had an increased odds of clustering (69.7% vs. 59.6%, OR: 1.9, 95% CI 0.6-6.2, P = 0.409). Using multivariate logistic analysis, there is significantly increased odds of clustering when eGFR is |
| Databáze: | OpenAIRE |
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