Chronic Hypoxia–Induced Angiogenesis Normalizes Blood Pressure in Spontaneously Hypertensive Rats
| Autor: | Jean-Sébastien Silvestre, Micheline Duriez, Clément Cochain, Philippe Bonnin, Bernard I. Levy, Céline Loinard, José Vilar, Ludovic Waeckel |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Time Factors Physiology Angiogenesis Neovascularization Physiologic Hemodynamics Blood Pressure Rats Inbred WKY Prehypertension Rats Inbred SHR Internal medicine medicine Animals cardiovascular diseases Cardiac Output Hypoxia Muscle Skeletal business.industry Heart Hypoxia (medical) Chronic hypoxia Rats medicine.anatomical_structure Endocrinology Blood pressure Chronic Disease Hypertension Circulatory system Vascular resistance Vascular Resistance medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation Research. 103:761-769 |
| ISSN: | 1524-4571 0009-7330 |
| DOI: | 10.1161/circresaha.108.182758 |
| Popis: | We hypothesized that activation of angiogenesis by chronic hypoxia may affect vascular resistance and, subsequently, blood pressure levels in spontaneously hypertensive rats (SHRs). Five-week-old prehypertensive SHRs and age-matched normotensive Wistar–Kyoto (WKY) rats (n=8 per group) were maintained under normobaric normoxic or hypoxic (10% O 2 ) conditions for 8 weeks. Three weeks later, the systolic blood pressure was lower by 26% in hypoxic SHRs compared to normoxic SHRs ( P P P P P P |
| Databáze: | OpenAIRE |
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