Staphylococcus aureus nasal isolates from healthy individuals cause highly variable host cell responses in vitro: the Tromsø Staph and Skin Study
| Autor: | Fatemeh Askarian, Johanna U. Ericson Sollid, Maria Sangvik, Lars Snipen, Anne-Merethe Hanssen, Mona Johannessen |
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| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Nasal cavity Adult Keratinocytes Staphylococcus aureus Genotype Biology medicine.disease_cause Bacterial Adhesion Microbiology medicine Immunology and Allergy Humans General Immunology and Microbiology Virulence Healthy population Biofilm Genetic Variation General Medicine Phenotypic trait Staphylococcal Infections In vitro Endocytosis Molecular Typing Infectious Diseases medicine.anatomical_structure Phenotype Healthy individuals Biofilms Carrier State Cytokines Nasal Cavity |
| Zdroj: | Pathogens and disease. 70(2) |
| ISSN: | 2049-632X |
| Popis: | Studies on Staphylococcus aureus populations colonizing the nasal cavity reveal that some bacterial strains are more common, while others are rarely found. This study included five isolates with the most common spa types and five isolates with rare spa types from healthy population. Selected phenotypic traits and genomic content among nasal S. aureus isolates were compared. Besides the rather similar growth rates, our data revealed a high diversity among isolates; that is, in biofilm formation, the ability to attach to and be internalized in keratinocytes as well as ability to induce pro- and anti-inflammatory cytokines. The results showed that S. aureus isolates from healthy hosts are phenotypically diverse and cause highly variable host cell responses. Therefore, generalizing the results from one S. aureus isolate to all is highly questionable. |
| Databáze: | OpenAIRE |
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