Effect of losartan on muscle sympathetic activity and baroreceptor function in systemic hypertension
| Autor: | Frank Enseleit, Thomas F. Lüscher, Rémy Chenevard, Georg Noll, Markus Béchir |
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| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Angiotensin receptor Baroreceptor Sympathetic Nervous System Adrenergic Pressoreceptors 610 Medicine & health Baroreflex Losartan 2705 Cardiology and Cardiovascular Medicine Internal medicine Medicine Humans Receptor Muscle Skeletal business.industry Middle Aged Angiotensin II Blockade Endocrinology Hypertension Cardiology 10209 Clinic for Cardiology Cardiology and Cardiovascular Medicine business Angiotensin II Type 1 Receptor Blockers medicine.drug |
| Popis: | Angiotensin II directly stimulates muscle sympathetic nerve activity and facilitates adrenergic sympathetic transmission. The hypotheses that the chronic blockade of angiotensin II receptors (AT(1) type) reduces muscle sympathetic activity and that there is an interaction with baroreceptor function in patients with mild to moderate hypertension were investigated. Muscle sympathetic nerve activity decreased from 51.7 +/- 3.5 to 45.9 +/- 4.2 bursts/min (p = 0.022), and cardiac baroreceptor sensitivity increased from 3.2 +/- 1.3 to 4.9 +/- 1.8 ms/mm Hg (p = 0.007). This study for the first time demonstrates that in hypertensive patients, chronic AT(1) receptor antagonism inhibits muscle sympathetic nerve activity and that baroreceptor function is improved under these conditions. |
| Databáze: | OpenAIRE |
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