New Terpenoids from the Corticioid Fungus Punctularia atropurpurascens and their Antimycobacterial Evaluation

Autor:	Daniel Acero, Firoz Shah Tuglak Khan, Abraham J. Medina-Ortiz, Isabel Rivero-Cruz, Huzefa A. Raja, Laura Flores-Bocanegra, Carlos A. Fajardo-Hernández, Baojie Wan, Scott G. Franzblau, Shabnam Hematian, Mario Figueroa
Rok vydání:	2022
Předmět:	Pharmacology Molecular Structure Complementary and alternative medicine Terpenes Basidiomycota Organic Chemistry Drug Discovery Fungi Pharmaceutical Science Molecular Medicine Crystallography X-Ray Anti-Bacterial Agents Analytical Chemistry
Zdroj:	Planta Medica. 88:729-734
ISSN:	1439-0221 0032-0943
DOI:	10.1055/a-1786-8072
Popis:	Chemical investigation of Punctularia atropurpurascens strain HM1 (Punctulariaceae), a corticioid isolated from a decorticated piece of Quercus bark collected in Bosque de Tlalpan, Mexico City, led to the isolation of a new drimane, 1-α-hydroxy-isodrimenine (1) and a new tetrahydroxy kauranol, 16-hydroxy-phlebia-nor-kauranol (2), together with the known N-phenylacetamide (3). Structures of all compounds were elucidated by spectroscopic and spectrometric methods, and the absolute configuration of 1 and 2 was confirmed via single-crystal X-ray crystallography. The isolated compounds showed modest antimycobacterial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4c1e6e535881aeac4fd1e4716d544f https://doi.org/10.1055/a-1786-8072 Zobrazit plný text záznamu