Distinct serum cytokines in AIDS-related skin diseases
| Autor: | Gailen D. Marshall, Joan Breuer-McHam, Dorothy E. Lewis, Madeleine Duvic |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Immunology Human immunodeficiency virus (HIV) medicine.disease_cause Interferon-gamma Acquired immunodeficiency syndrome (AIDS) Virology Psoriasis Medicine Humans Sarcoma Kaposi Acquired Immunodeficiency Syndrome business.industry Tumor Necrosis Factor-alpha Pruritus virus diseases Interleukin medicine.disease CD4 Lymphocyte Count Interleukin-10 Serum cytokine Molecular Medicine Cytokines Tumor necrosis factor alpha Sarcoma business |
| Zdroj: | Viral immunology. 11(4) |
| ISSN: | 0882-8245 |
| Popis: | To determine whether common skin diseases associated with human immunodeficiency virus (HIV) were distinguishable based on the pattern of serum cytokine expression, we studied patients with psoriasis, pruritus, and Kaposi's sarcoma (KS) for levels of tumor necrosis factor (TNF)-alpha, interferon-gamma (IFN-y), interleukin (IL)-10, and IL-4. Thirty-two HIV-positive (HIV+) patients including 8 with KS, 11 with psoriasis, and 13 with pruritus along with 16 HIV-negative subjects with psoriasis were studied. IFN-gamma levels were highest in sera of HIV+ patients with psoriasis (p = 0.040). By contrast, TNF-alpha and IL-10 levels were highest in sera of HIV+ patients with pruritus (p = 0.012). Detectable levels of all cytokines in these patients were remarkably higher than for healthy adults. These results suggest that common skin diseases associated with HIV infection and AIDS can be distinguished by the production of unique cytokines. |
| Databáze: | OpenAIRE |
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