Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules
| Autor: | Yoshikatsu Kanai, Rie Noshiro, Hitoshi Endou, Hiroki Miyazaki, Promsuk Jutabha, Sophapun Ekaratanawong, Michio Takeda, Naohiko Anzai, Samaisukh Sophasan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Time Factors
Organic anion transporter 1 Estrone Population Organic Anion Transporters Sodium-Independent Tritium Glutarates Kidney Tubules Proximal Mice Organic Anion Transport Protein 1 medicine Animals Humans Carbon Radioisotopes education Cells Cultured Dicarboxylic Acid Transporters Pharmacology education.field_of_study Kidney biology Liver-Specific Organic Anion Transporter 1 Chemistry Reabsorption lcsh:RM1-950 Apical membrane Immunohistochemistry Up-Regulation medicine.anatomical_structure lcsh:Therapeutics. Pharmacology Biochemistry Organic anion transport biology.protein Biophysics Molecular Medicine p-Aminohippuric Acid Efflux Organic anion |
| Zdroj: | Journal of Pharmacological Sciences, Vol 94, Iss 3, Pp 297-304 (2004) |
| ISSN: | 1347-8613 |
| Popis: | Human organic anion transporter OAT4 is expressed in the kidney and placenta and mediates high-affinity transport of estrone-3-sulfate (E1S). Because a previous study demonstrated no trans-stimulatory effects by E1S, the mode of organic anion transport via OAT4 remains still unclear. In the present study, we examined the driving force of OAT4 using mouse proximal tubular cells stably expressing OAT4 (S2 OAT4). OAT4-mediated E1S uptake was inhibited by glutarate (GA) (IC50: 1.25 mM) and [14C]GA uptake via S2 OAT4 was significantly trans-stimulated by unlabeled GA (5 mM) (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|