Clinicopathologic Features of Familial Nonmedullary Thyroid Carcinoma
| Autor: | Zhonghua Shang, Hong-Feng Liu, Bo Zhang, Qiong Wu, Yu-Fang Fan, Xiaoyi Li, Wei-Sheng Gao, Xiao Yang, Yong Xie, Yuewu Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Thyroid nodules Adult Male Proto-Oncogene Proteins B-raf medicine.medical_specialty Pathology Clinical Pathology Nonmedullary lcsh:Medicine Thyroiditis Thyroid carcinoma Familial Internal medicine medicine Carcinoma Humans Genetic Predisposition to Disease Thyroid Neoplasms Stage (cooking) Lymph node Retrospective Studies Clinical pathology business.industry lcsh:R Thyroid Carcinoma Retrospective cohort study General Medicine Middle Aged medicine.disease Carcinoma Papillary medicine.anatomical_structure Thyroid Cancer Papillary Mutation Original Article Female business |
| Zdroj: | Chinese Medical Journal, Vol 128, Iss 8, Pp 1037-1041 (2015) Chinese Medical Journal |
| ISSN: | 0366-6999 |
| Popis: | Background: Familial nonmedullary thyroid carcinoma (FNMTC) is a variant of nonmedullary thyroid carcinoma(NMTC) with particular clinicopathologic features. In recent years, a number of studies have shown that FNMTC is more invasive than sporadic NMTC(SNMTC). The purpose of this study was to explore the differences in clinicopathologic features of FNMTC between different types of families and to determine in which of these families more invasive FNMTC occurred. Methods: We retrospectively reviewed all patients with thyroid carcinoma admitted to Peking Union Medical College Hospital from January 2009 to July 2013 in the database. Of all 2000 cases, 55 met the inclusive criteria for FNMTC and were studied. There are two different grouping methods. The first is that all samples were allocated to families with three or more first-degree relatives affected (FNMTC-3 group) and families with only two affected first-degree relatives (FNMTC-2 group). The second is that all patients were divided into families with three or more affected first-degree relatives over two generations (FNMTC-3-2 group) and the other families. We compared the clinicopathologic features such as sex, age, tumor size, multifocality, location, complications by thyroiditis, complications by benign thyroid nodules, surgical procedure, capsule invasion, histological type, lymph node metastases, tumor node metastasis stage, and BRAF mutation between FNMTC-2 group and FNMTC-3 group. We also made the same comparison between FNMTC-3-2 group and other families. Results: No pronounced differences in clinicopathological features were present between FNMTC-2 group and FNMTC-3 group. The proportion of FNMTC-3-2 group aged |
| Databáze: | OpenAIRE |
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