Alteration of inflammation marker levels with alfa keto analogs in diabetic rats
| Autor: | YD Bildaci, H Bulut, OC Elcioglu, M Gursu, R Kazancioglu |
|---|---|
| Přispěvatelé: | KAZANCIOĞLU, Rümeyza |
| Rok vydání: | 2022 |
| Předmět: |
Inflammation
Male Alfa keto analogs diabetic nefropathy interleukin rat Interleukin-6 Nitrogen Tumor Necrosis Factor-alpha Interleukin-18 General Medicine Keto Acids Diabetes Mellitus Experimental Interleukin-10 Rats Rats Sprague-Dawley Animals Kidney Failure Chronic Diabetic Nephropathies Amino Acids Serum Albumin Bildaci Y. D. Bulut H. Elcioglu O. C. Gursu M. Kazancioglu R. -Alteration of inflammation marker levels with alfa keto analogs in diabetic rats.- Nigerian journal of clinical practice cilt.25 sa.9 ss.1452-1456 2022 |
| Zdroj: | Nigerian Journal of Clinical Practice; Vol. 25 No. 9 (2022); 1452-1456 |
| ISSN: | 1119-3077 |
| Popis: | Background: Diabetes mellitus is the most well‑known and common cause of end‑stage renal disease. Excessive inflammatory processes were hypothesized to be one of the reasons for progression to end‑stage disease. Even though progression to end stage disease tried to be prevented with some dietary measures such as lowering nitrogen in diet, none of the methods tried were successful enough.Aims: In our study, we aimed to determine the effects of alfa keto analog use in altering levels of inflammatory markers when added to dietary program in a diabetic rat model. Patients and Methods: The study wasformed on 22 male Sprague Dawley rats with streptozocine induced diabetic nephropathy. Both groups were fed with low protein diet except for study group with added alfa keto analogs. Biochemical values and inflammatory markers were studied with ELISA assay. Results: Significant difference in serum albumin was found between study group and control group following administration of alfa keto analogs (p |
| Databáze: | OpenAIRE |
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