Occupational exposure to high-frequency electromagnetic fields and brain tumor risk in the INTEROCC study:An individualized assessment approach

Autor: Vila, Javier, Turner, Michelle C, Gracia-Lavedan, Esther, Figuerola, Jordi, Bowman, Joseph D, Kincl, Laurel, Richardson, Lesley, Benke, Geza, Fleming, Sarah, Hours, Martine, Krewski, Daniel, McLean, Dave, Parent, Marie-Elise, Sadetzki, Siegal, Schlaefer, Klaus, Schlehofer, Brigitte, Schüz, Joachim, Siemiatycki, Jack, van Tongeren, Martie, Cardis, Elisabeth
Přispěvatelé: Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), National Institute for Occupational Safety and Health [Cincinnati] (NIOSH), Centers for Disease Control and Prevention (CDC), Oregon State University (OSU), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Monash University [Clayton], Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), University of Ottawa [Ottawa], Massey University, Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Sackler Faculty of Medicine, Tel Aviv University [Tel Aviv], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Manchester [Manchester]
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: INTEROCC STUDY GROUP 2018, ' Occupational exposure to high-frequency electromagnetic fields and brain tumor risk in the INTEROCC study : An individualized assessment approach ', Environment International, vol. 119, pp. 353-365 . https://doi.org/10.1016/j.envint.2018.06.038
Environ Int
Environment International
Environment International, Elsevier, 2018, 119, pp. 353-365. ⟨10.1016/j.envint.2018.06.038⟩
ISSN: 0160-4120
Popis: INTRODUCTION: In 2011, the International Agency for Research on Cancer classified radiofrequency (RF) electromagnetic fields (EMF) as possibly carcinogenic to humans (group 2B), although the epidemiological evidence for the association between occupational exposure to RF-EMF and cancer was judged to be inadequate, due in part to limitations in exposure assessment. This study examines the relation between occupational RF and intermediate frequency (IF) EMF exposure and brain tumor (glioma and meningioma) risk in the INTEROCC multinational population-based case-control study (with nearly 4000 cases and over 5000 controls), using a novel exposure assessment approach.METHODS: Individual indices of cumulative exposure to RF and IF-EMF (overall and in specific exposure time windows) were assigned to study participants using a source-exposure matrix and detailed interview data on work with or nearby EMF sources. Conditional logistic regression was used to investigate associations with glioma and meningioma risk.RESULTS: Overall, around 10% of study participants were exposed to RF while only 1% were exposed to IF-EMF. There was no clear evidence for a positive association between RF or IF-EMF and the brain tumors studied, with most results showing either no association or odds ratios (ORs) below 1.0. The largest adjusted ORs were obtained for cumulative exposure to RF magnetic fields (as A/m-years) in the highest exposed category (≥90th percentile) for the most recent exposure time window (1-4 years before the diagnosis or reference date) for both glioma, OR = 1.62 (95% confidence interval (CI): 0.86, 3.01) and meningioma (OR = 1.52, 95% CI: 0.65, 3.55).CONCLUSION: Despite the improved exposure assessment approach used in this study, no clear associations were identified. However, the results obtained for recent exposure to RF electric and magnetic fields are suggestive of a potential role in brain tumor promotion/progression and should be further investigated.
Databáze: OpenAIRE
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