Definitive Radiotherapy in the Management of Stage I and II Carcinomas of the Glottis
| Autor: | William C. Constable, Cynthia A. Spaulding, Kelly, C. R. Kersh, Seung S. Hahn, Robert W. Cantrell |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Larynx Glottis medicine.medical_specialty Voice Quality medicine.medical_treatment Population Stage ii 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Cobalt Radioisotopes 030223 otorhinolaryngology education Laryngeal Neoplasms Definitive radiotherapy Survival analysis Aged Retrospective Studies Aged 80 and over education.field_of_study business.industry Radiotherapy Dosage General Medicine Middle Aged medicine.disease Surgery Radiation therapy medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Radioisotope Teletherapy business Follow-Up Studies |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 98:235-239 |
| ISSN: | 1943-572X 0003-4894 |
| DOI: | 10.1177/000348948909800314 |
| Popis: | Definitive radiotherapy for early glottic carcinoma continues to offer excellent control and the advantage of voice preservation. In the 13 years from January 1972 through December 1984, there were 187 patients diagnosed with squamous cell carcinoma of the glottis at the University of Virginia Medical Center. One hundred forty-eight patients were treated with definitive radiotherapy as the initial management. The 3-year disease-free survival for the irradiated population was 93.6% in stage I and 75.5% in stage II. Twenty patients had recurrences following radiotherapy, and 13 of 20 were successfully surgically salvaged for an overall determinate survival of 100% in stage I and 85.7% in stage II at 3 years. These statistics are comparable to those from our previous 16-year review of 147 patients from 1956 through 1971. Factors of prognostic significance were persistent hoarseness after radiotherapy, impaired cord mobility, subglottic extension, and multiple sites of involvement in stage I. We conclude that definitive radiotherapy offers excellent survival and that a majority of the small number of treatment failures can be managed with surgical salvage. |
| Databáze: | OpenAIRE |
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