Pharmacologic ciliary body ablation for chronic glaucoma in dogs: A retrospective review of 108 eyes from 2013 to 2018
| Autor: | Jessica M. Stine, Tammy M. Michau, Anja Welihozkiy, Martha E. Julien, Terri L. Baldwin, Simone A. Schechtmann |
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| Rok vydání: | 2020 |
| Předmět: |
Ablation Techniques
Male medicine.medical_specialty Intraocular pressure Triamcinolone acetonide genetic structures 040301 veterinary sciences medicine.medical_treatment Enucleation Glaucoma Dexamethasone 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine Dexamethasone Sodium Phosphate Ophthalmology medicine Animals Dog Diseases Retrospective Studies General Veterinary business.industry Ciliary Body 04 agricultural and veterinary sciences medicine.disease Ablation eye diseases Intravitreal Injections 030221 ophthalmology & optometry Female Gentamicin sense organs Gentamicins Phthisis bulbi business medicine.drug |
| Zdroj: | Veterinary Ophthalmology. 24:125-130 |
| ISSN: | 1463-5224 1463-5216 |
| DOI: | 10.1111/vop.12816 |
| Popis: | Objective To evaluate the long-term outcome and efficacy of intravitreal injection of gentamicin and dexamethasone sodium phosphate (IVGD) or triamcinolone in end-stage glaucoma patients and determine pre-procedure prognostic indicators of success and post-operative complications. Procedure Medical records were reviewed for 108 dogs (108 eyes) treated with intravitreal gentamicin with or without dexamethasone sodium phosphate or triamcinolone for glaucoma between 2013 and 2018 with 3 months of minimum follow-up. Signalment and clinical findings, including type of glaucoma, pre-procedure intraocular pressure (IOP), chronicity, procedure protocol, and outcome were recorded. Success was defined as an intraocular pressure of ≤25 mm Hg at the time of last re-examination or no ocular hypotensive medications at 3 months or longer post-injection. Results The overall success rate for pharmacologic ablation was 95%. The success rate for dogs receiving no ocular hypotensive medications was 86%. Seventy-six eyes (70.4%) had primary glaucoma, and 32 eyes (29.6%) had secondary glaucoma. Age at the time of injection had no effect on initial success but did in final success (P =-.03) for dogs requiring repeat injections. Cocker Spaniels required the most repeat 2nd and 3rd injections (3/12 dogs) and (2/4 dogs), respectively. No preoperative variable significantly affected the success rate. The most common complications were phthisis bulbi (59.2%), corneal edema (25.9%), and ulcerative keratitis (22.3%). Uncontrolled IOP resulted in enucleation in two dogs (1.8%). Conclusions Pharmacologic ablation has a high overall success rate in lowering IOP to ≤25 mm Hg short-term in blind, glaucomatous canine eyes. Type of glaucoma, pre-procedure IOP, chronicity, and protocol did not affect success. |
| Databáze: | OpenAIRE |
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