Neutrophils in respiratory syncytial virus infection: A target for asthma prevention
| Autor: | Ruben J. Geerdink, Louis Bont, Linde Meyaard, Janesh Pillay |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
INFLUENZA-VIRUS
AIRWAY INFLAMMATION Neutrophils respiratory syncytial virus Virus Replication Viral Respiratory Tract Infection Cell Movement NK Natural killer HUMAN IMMUNODEFICIENCY VIRUS-1 immunopathology Immunology and Allergy Lung treatment Respiratory tract infections Neutrophil LONGITUDINAL BIRTH-COHORT DC Dendritic cell Respiratory Syncytial Viruses 3. Good health medicine.anatomical_structure Bronchiolitis RSV Respiratory syncytial virus TLR Toll-like receptor MMP Matrix metalloproteinase MPO Myeloperoxidase Immunology neutrophil extracellular traps Respiratory Syncytial Virus Infections EXTRACELLULAR TRAPS Biology Lung injury OBSTRUCTIVE PULMONARY-DISEASE Article EARLY-LIFE HNP Human neutrophil peptide Lower respiratory tract infection medicine Animals Humans asthma prevention Asthma immune regulation Infant CHILDHOOD ASTHMA LRTI Lower respiratory tract infection respiratory syncytial virus bronchiolitis RSV BRONCHIOLITIS Neutrophil extracellular traps asthma medicine.disease PTX Pentraxin NET Neutrophil extracellular trap lower respiratory tract infection LUNG INJURY ROS Reactive oxygen species |
| Zdroj: | The Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology, 136(4), 838. Mosby Inc. |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/j.jaci.2015.06.034 |
| Popis: | Lower respiratory tract infections by respiratory syncytial virus (RSV) are the foremost cause of infant hospitalization and are implicated in lasting pulmonary impairment and the development of asthma. Neutrophils infiltrate the airways of pediatric patients with RSV-induced bronchiolitis in vast numbers: approximately 80% of infiltrated cells are neutrophils. However, why neutrophils are recruited to the site of viral respiratory tract infection is not clear. In this review we discuss the beneficial and pathologic contributions of neutrophils to the immune response against RSV infection. Neutrophils can limit viral replication and spread, as well as stimulate an effective antiviral adaptive immune response. However, low specificity of neutrophil antimicrobial armaments allows for collateral tissue damage. Neutrophil-induced injury to the airways during the delicate period of infant lung development has lasting adverse consequences for pulmonary architecture and might promote the onset of asthma in susceptible subjects. We suggest that pharmacologic modulation of neutrophils should be explored as a viable future therapy for severe RSV-induced bronchiolitis and thereby prevent the inception of subsequent asthma. The antiviral functions of neutrophils suggest that targeting of neutrophils in patients with RSV-induced bronchiolitis is best performed under the umbrella of antiviral treatment. |
| Databáze: | OpenAIRE |
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