Changes in tissue metalloproteinase inhibitor-1 and matrix metalloproteinases during tumor development and metastasizing in mice
| Autor: | S. Ya. Zhanaeva, T. G. Filatova, Tatyana V. Alexeenko, V. M. Belichenko, Tatyana A. Korolenko |
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| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Metalloproteinase Inhibitor 1 Gadolinium Matrix metalloproteinase Matrix Metalloproteinase Inhibitors General Biochemistry Genetics and Molecular Biology Metastasis Carcinoma Lewis Lung Mice medicine Macrophage Animals Tumor growth Neoplasm Metastasis Lung Control level Tissue Inhibitor of Metalloproteinase-1 Chemistry General Medicine medicine.disease Gene Expression Regulation Neoplastic Mice Inbred C57BL medicine.anatomical_structure Liver Cancer research Adenocarcinoma |
| Zdroj: | Bulletin of experimental biology and medicine. 150(2) |
| ISSN: | 1573-8221 |
| Popis: | Tissue inhibitor of matrix metalloproteinases type 1, inhibiting the majority of matrix metalloproteinases, can both suppress and stimulate tumor growth. The concentrations and activities of tissue matrix metalloproteinase inhibitor-1 were measured in C57Bl/6 mice during progression and metastasizing of Lewis lung adenocarcinoma. Activities of matrix metalloproteinases in tumor tissue of mice were lower than in liver and lung tissues of intact animals. Serum concentration of tissue inhibitor increased significantly during the development of Lewis lung adenocarcinoma. Macrophage depression (injection of gadolinium chloride associated with a decrease in metastasis number) decreased serum concentration of tissue inhibitor, but it did not attain the control level observed in intact mice. These findings attest to a pleiotropic antitumor effect of tissue matrix metalloproteinase inhibitor-1 reflecting disorders in matrix metalloproteinase regulation during the progress of Lewis lung adenocarcinoma in mice. |
| Databáze: | OpenAIRE |
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